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LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate
BACKGROUND: Lrrk2, a gene linked to Parkinson’s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes. At the presynaptic site, LRRK2 associates with synaptic vesicles through interaction with a panel of presynaptic pr...
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| Formato: | Artigo |
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| Idioma: | en |
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BioMed Central
2016
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4711005/ https://ncbi.nlm.nih.gov/pubmed/26758690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0066-z |
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