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High-affinity self-reactive human antibodies by design and selection: targeting the integrin ligand binding site.

A strategy for the design and selection of human antibodies that bind receptors is described. We have demonstrated the validity of the approach by producing semi-synthetic human antibodies that bind integrins alpha v beta 3 and alpha IIb beta 3 with high affinity (10(-10) M). The selected antibodies...

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Main Authors:	Barbas, C F, Languino, L R, Smith, J W, Keung, W M, Vallee, B L, Giovannangeli, C, Thuong, N T, Hélène, C, Blaskó, A, Bruice, T C, Chi, M M, Manchester, J K, Basuray, R, Mahendra, S, Strickler, R C, McDougal, D B, Lowry, O H, Rosenthal, J J, Gilly, W F, Tugendreich, S, Boguski, M S, Seldin, M S, Hieter, P, Deutsch, C, Chen, L Q, Prabhakar, N R, Cao, H, Lowe, J A, Snider, R M, Kim, S, Ribas de Pouplana, L, Schimmel, P, Anderson, D J, Abbott, A F, Jack, R M, Mikayama, T, Nakano, T, Gomi, H, Nakagawa, Y, Liu, Y C, Sato, M, Iwamatsu, A, Ishii, Y, Weiser, W Y, Ishizaka, K, Campbell, I L, Abraham, C R, Masliah, E, Kemper, P, Inglis, J D, Oldstone, M B, Mucke, L, Huang, L, Berkelman, T, Franklin, A E, Hoffman, N E, Lin, Y, Kimmel, L H, Myles, D G, Primakoff, P, Schulz, R A, The, S M, Hogue, D A, Galewsky, S, Guo, Q, Barnes, S, Merchant, V, Mahmud, F, Lee, H C, Fellenz-Maloney, M P, Liscovitch, M, Blusztajn, J K, Enssle, J, Kugler, W, Hentze, M W, Kulozik, A E, Li, Y Y, Yeh, E, Hays, T, Bloom, K, Noolandi, J, Forsyth, R, Shi, A C, White, A, Tomfohrde, J, Stewart, E, Barnes, R, Le Paslier, D, Weissenbach, J, Cavalli-Sforza, L, Farrer, L, Bowcock, A, Huang, H, Auerbach, R, Kolman, J L, Taylor, N, Marshak, D R, Miller, G, Bethel, C. A., Murugesh, D., Harrison, M. R., Mohandas, N., Rubin, E. M., Mathisen, P M, Pease, S, Garvey, J, Hood, L, Readhead, C, Rettori, V, Belova, N, Dees, W L, Nyberg, C L, Gimeno, M, McCann, S M, Sculptoreanu, A, Rotman, E, Takahashi, M, Scheuer, T, Catterall, W A, Fraidenraich, D, Peña, C, Isola, E L, Lammel, E M, Coso, O, Añel, A D, Pongor, S, Baralle, F, Torres, H N, Flawia, M M, Chung, H H, Benson, D R, Cornish, V W, Schultz, P G, Kibbey, M C, Jucker, M, Weeks, B S, Neve, R L, Van Nostrand, W E, Kleinman, H K, Prieto, A L, Edelman, G M, Crossin, K L, Paria, B C, Huet-Hudson, Y M, Dey, S K, Dykhuizen, D E, Polin, D S, Dunn, J J, Wilske, B, Preac-Mursic, V, Dattwyler, R J, Luft, B J, Passmore, B K, Sanger, M, Chin, L S, Falk, B W, Bruening, G, Kim, Y T, Richardson, C C, Zheng, C J, Byers, B, Moolgavkar, S H, Dowding, A J, Scholes, J, Seder, R A, Gazzinelli, R, Sher, A, Paul, W E, Matsusaka, T, Fujikawa, K, Nishio, Y, Mukaida, N, Matsushima, K, Kishimoto, T, Akira, S, Hanna, P C, Acosta, D, Collier, R J, Charlton, R E, Webster, F X, Zhang, A, Schal, C, Liang, D, Sreng, I, Roelofs, W L, Fahmy, K, Jäger, F, Beck, M, Zvyaga, T A, Sakmar, T P, Siebert, F, Kew, M C, Miller, R H, Chen, H S, Tennant, B C, Purcell, R H, Hendrick, J P, Langer, T, Davis, T A, Hartl, F U, Wiedmann, M, Wesson, D M, McLain, D K, Oliver, J H, Piesman, J, Collins, F H, Rideout, D, Bustamante, A, Siuzdak, G, Wang, J B, Imai, Y, Eppler, C M, Gregor, P, Spivak, C E, Uhl, G R, Dascal, N, Schreibmayer, W, Lim, N F, Wang, W, Chavkin, C, DiMagno, L, Labarca, C, Kieffer, B L, Gaveriaux-Ruff, C, Trollinger, D, Antunes-Rodrigues, J, Marubayashi, U, Favaretto, A L, Gutkowska, J
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC47701/ https://ncbi.nlm.nih.gov/pubmed/7694276 https://ncbi.nlm.nih.gov/pmc/articles/PMC47702/ https://ncbi.nlm.nih.gov/pubmed/8234248 https://ncbi.nlm.nih.gov/pmc/articles/PMC47703/ https://ncbi.nlm.nih.gov/pubmed/8234249 https://ncbi.nlm.nih.gov/pmc/articles/PMC47704/ https://ncbi.nlm.nih.gov/pubmed/7694277 https://ncbi.nlm.nih.gov/pmc/articles/PMC47705/ https://ncbi.nlm.nih.gov/pubmed/8234250 https://ncbi.nlm.nih.gov/pmc/articles/PMC47706/ https://ncbi.nlm.nih.gov/pubmed/8234251 https://ncbi.nlm.nih.gov/pmc/articles/PMC47707/ https://ncbi.nlm.nih.gov/pubmed/8234252 https://ncbi.nlm.nih.gov/pmc/articles/PMC47708/ https://ncbi.nlm.nih.gov/pubmed/8234253 https://ncbi.nlm.nih.gov/pmc/articles/PMC47709/ https://ncbi.nlm.nih.gov/pubmed/8234254 https://ncbi.nlm.nih.gov/pmc/articles/PMC47710/ https://ncbi.nlm.nih.gov/pubmed/7694278 https://ncbi.nlm.nih.gov/pmc/articles/PMC47711/ https://ncbi.nlm.nih.gov/pubmed/8234255 https://ncbi.nlm.nih.gov/pmc/articles/PMC47712/ https://ncbi.nlm.nih.gov/pubmed/8234256 https://ncbi.nlm.nih.gov/pmc/articles/PMC47713/ https://ncbi.nlm.nih.gov/pubmed/7694279 https://ncbi.nlm.nih.gov/pmc/articles/PMC47714/ https://ncbi.nlm.nih.gov/pubmed/8234257 https://ncbi.nlm.nih.gov/pmc/articles/PMC47715/ https://ncbi.nlm.nih.gov/pubmed/8234258 https://ncbi.nlm.nih.gov/pmc/articles/PMC47716/ https://ncbi.nlm.nih.gov/pubmed/8234259 https://ncbi.nlm.nih.gov/pmc/articles/PMC47717/ https://ncbi.nlm.nih.gov/pubmed/7694280 https://ncbi.nlm.nih.gov/pmc/articles/PMC47718/ https://ncbi.nlm.nih.gov/pubmed/8234260 https://ncbi.nlm.nih.gov/pmc/articles/PMC47719/ https://ncbi.nlm.nih.gov/pubmed/8234261 https://ncbi.nlm.nih.gov/pmc/articles/PMC47720/ https://ncbi.nlm.nih.gov/pubmed/8234262 https://ncbi.nlm.nih.gov/pmc/articles/PMC47721/ https://ncbi.nlm.nih.gov/pubmed/8234263 https://ncbi.nlm.nih.gov/pmc/articles/PMC47722/ https://ncbi.nlm.nih.gov/pubmed/8234264 https://ncbi.nlm.nih.gov/pmc/articles/PMC47723/ https://ncbi.nlm.nih.gov/pubmed/8234265 https://ncbi.nlm.nih.gov/pmc/articles/PMC47724/ https://ncbi.nlm.nih.gov/pubmed/8234266 https://ncbi.nlm.nih.gov/pmc/articles/PMC47725/ https://ncbi.nlm.nih.gov/pubmed/7980734 https://ncbi.nlm.nih.gov/pmc/articles/PMC47726/ https://ncbi.nlm.nih.gov/pubmed/7694281 https://ncbi.nlm.nih.gov/pmc/articles/PMC47727/ https://ncbi.nlm.nih.gov/pubmed/7694282 https://ncbi.nlm.nih.gov/pmc/articles/PMC47728/ https://ncbi.nlm.nih.gov/pubmed/7694283 https://ncbi.nlm.nih.gov/pmc/articles/PMC47729/ https://ncbi.nlm.nih.gov/pubmed/8234267 https://ncbi.nlm.nih.gov/pmc/articles/PMC47730/ https://ncbi.nlm.nih.gov/pubmed/8234268 https://ncbi.nlm.nih.gov/pmc/articles/PMC47731/ https://ncbi.nlm.nih.gov/pubmed/8234269 https://ncbi.nlm.nih.gov/pmc/articles/PMC47732/ https://ncbi.nlm.nih.gov/pubmed/7694284 https://ncbi.nlm.nih.gov/pmc/articles/PMC47733/ https://ncbi.nlm.nih.gov/pubmed/8234270 https://ncbi.nlm.nih.gov/pmc/articles/PMC47734/ https://ncbi.nlm.nih.gov/pubmed/8234271 https://ncbi.nlm.nih.gov/pmc/articles/PMC47735/ https://ncbi.nlm.nih.gov/pubmed/8234272 https://ncbi.nlm.nih.gov/pmc/articles/PMC47736/ https://ncbi.nlm.nih.gov/pubmed/8234273 https://ncbi.nlm.nih.gov/pmc/articles/PMC47737/ https://ncbi.nlm.nih.gov/pubmed/8234274 https://ncbi.nlm.nih.gov/pmc/articles/PMC47738/ https://ncbi.nlm.nih.gov/pubmed/8234275 https://ncbi.nlm.nih.gov/pmc/articles/PMC47739/ https://ncbi.nlm.nih.gov/pubmed/7901851 https://ncbi.nlm.nih.gov/pmc/articles/PMC47740/ https://ncbi.nlm.nih.gov/pubmed/8234276 https://ncbi.nlm.nih.gov/pmc/articles/PMC47741/ https://ncbi.nlm.nih.gov/pubmed/8234277 https://ncbi.nlm.nih.gov/pmc/articles/PMC47742/ https://ncbi.nlm.nih.gov/pubmed/11607437 https://ncbi.nlm.nih.gov/pmc/articles/PMC47743/ https://ncbi.nlm.nih.gov/pubmed/7901852 https://ncbi.nlm.nih.gov/pmc/articles/PMC47744/ https://ncbi.nlm.nih.gov/pubmed/8234278 https://ncbi.nlm.nih.gov/pmc/articles/PMC47745/ https://ncbi.nlm.nih.gov/pubmed/8234279 https://ncbi.nlm.nih.gov/pmc/articles/PMC47746/ https://ncbi.nlm.nih.gov/pubmed/8234280 https://ncbi.nlm.nih.gov/pmc/articles/PMC47747/ https://ncbi.nlm.nih.gov/pubmed/8234281 https://ncbi.nlm.nih.gov/pmc/articles/PMC47748/ https://ncbi.nlm.nih.gov/pubmed/8234282 https://ncbi.nlm.nih.gov/pmc/articles/PMC47749/ https://ncbi.nlm.nih.gov/pubmed/8234283 https://ncbi.nlm.nih.gov/pmc/articles/PMC47750/ https://ncbi.nlm.nih.gov/pubmed/8234284
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High-affinity self-reactive human antibodies by design and selection: targeting the integrin ligand binding site.

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