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Repurposing tromethamine as inhaled therapy to treat CF airway disease
In cystic fibrosis (CF), loss of CF transmembrane conductance regulator (CFTR) anion channel activity causes airway surface liquid (ASL) pH to become acidic, which impairs airway host defenses. One potential therapeutic approach is to correct the acidic pH in CF airways by aerosolizing HCO(3)(–) and...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
American Society for Clinical Investigation
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4933331/ https://ncbi.nlm.nih.gov/pubmed/27390778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87535 |
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