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Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein.

Germ-line mutations in the p53 tumor suppressor gene have been observed in patients with Li-Fraumeni syndrome, brain tumors, second malignancies, and breast cancers. It is unclear whether all of these mutations have inactivated p53 and thereby provide an increased risk for cancer. Therefore, it is n...

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Detalhes bibliográficos
Main Authors:	Frebourg, T, Kassel, J, Lam, K T, Gryka, M A, Barbier, N, Andersen, T I, Børresen, A L, Friend, S H, Tsuchiya, K, Wang, W, Giebisch, G, Welling, P A, Jeggo, P A, Hafezparast, M, Thompson, A F, Broughton, B C, Kaur, G P, Zdzienicka, M Z, Athwal, R S, Ogata, K, Hojo, H, Aimoto, S, Nakai, T, Nakamura, H, Sarai, A, Ishii, S, Nishimura, Y, Siegert, F, Weijer, C J, Renz, H, Bradley, K L, Marrack, P, Gelfand, E W, Yoshida, K, Asaoka, Y, Nishizuka, Y, Oka, M, Sasaki, Y, Huang, J M, Xian, H, Bacaner, M, Morisaki, T, Gross, M, Morisaki, H, Pongratz, D, Zöllner, N, Holmes, E W, Cheung, A L, Koomey, J M, Butler, C A, Projan, S J, Fischetti, V A, Radany, E H, Brenner, M, Besnard, F, Bigornia, V, Bishop, J M, Deschepper, C F, De Rocquigny, H, Gabus, C, Vincent, A, Fournié-Zaluski, M C, Roques, B, Darlix, J L, Magnani, M, Rossi, L, Brandi, G, Schiavano, G F, Montroni, M, Piedimonte, G, Lemarchand, P, Jaffe, H A, Danel, C, Cid, M C, Kleinman, H K, Stratford-Perricaudet, L D, Perricaudet, M, Pavirani, A, Lecocq, J P, Crystal, R G, Madden, M S, Krezel, A M, Allen, R M, Ludden, P W, Shah, V K, Hsieh, P, Camerini-Otero, C S, Camerini-Otero, R D, Nilsson, T, Wattam, A R, Christensen, B M, Arase, H, Arase, N, Ogasawara, K, Good, R A, Onoé, K, Bowtell, D, Fu, P, Simon, M, Senior, P, Sun, Y, Hegamyer, G, Cheng, Y J, Hildesheim, A, Chen, J Y, Chen, I H, Cao, Y, Yao, K T, Colburn, N H, Masure, H R, Yovell, Y, Abrams, T W, Williams, D, Julesz, B, Mankin, A S, Zyrianova, I M, Kagramanova, V K, Garrett, R A, Zaret, K S, Milos, P, Lia, M, Bali, D, Gluecksohn-Waelsch, S, Lundberg, A S, McDevitt, H O, Noelle, R J, Roy, M, Shepherd, D M, Stamenkovic, I, Ledbetter, J A, Aruffo, A, Marini, A M, Paul, S M, Walling, D M, Edmiston, S N, Sixbey, J W, Abdel-Hamid, M, Resnick, L, Raab-Traub, N, Pan, T C, Zhang, R Z, Mattei, M G, Timpl, R, Chu, M L, Barik, S, Banerjee, A K, Sankoff, D, Leduc, G, Antoine, N, Paquin, B, Lang, B F, Cedergren, R, Bukrinsky, M I, Sharova, N, Dempsey, M P, Stanwick, T L, Bukrinskaya, A G, Haggerty, S, Stevenson, M, Stoops, J K, Kolodziej, S J, Schroeter, J P, Bretaudiere, J P, Wakil, S J, Panaccione, D G, Scott-Craig, J S, Pocard, J A, Walton, J D, Gordon, H, Ralston, E, Hall, Z W, Kumar, R, Atlas, I, Bao, W, O'Malley, D M, Sederoff, R R, Mancini, G M, Beerens, C E, Galjaard, H, Verheijen, F W, Hao, M H, Rackovsky, S, Liwo, A, Pincus, M R, Scheraga, H A, Zeuzem, S, Feick, P, Zimmermann, P, Haase, W, Kahn, R A, Schulz, I, Bermingham, E, Rohwer, S, Freeman, S, Wood, C, Virsolvy-Vergine, A, Leray, H, Kuroki, S, Lupo, B, Dufour, M, Bataille, D, Zazopoulos, E, Haseltine, W A, Liu, Q R, Mandiyan, S, Nelson, H, Nelson, N, Ciszak, E, Cody, V, Luft, J R, Northington, F J, Matherne, G P, Berne, R M, Park, Y W, Breslauer, K J
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC49511/ https://ncbi.nlm.nih.gov/pubmed/1631137 https://ncbi.nlm.nih.gov/pmc/articles/PMC49512/ https://ncbi.nlm.nih.gov/pubmed/1321439 https://ncbi.nlm.nih.gov/pmc/articles/PMC49513/ https://ncbi.nlm.nih.gov/pubmed/1631138 https://ncbi.nlm.nih.gov/pmc/articles/PMC49514/ https://ncbi.nlm.nih.gov/pubmed/1631139 https://ncbi.nlm.nih.gov/pmc/articles/PMC49515/ https://ncbi.nlm.nih.gov/pubmed/1631140 https://ncbi.nlm.nih.gov/pmc/articles/PMC49516/ https://ncbi.nlm.nih.gov/pubmed/1385874 https://ncbi.nlm.nih.gov/pmc/articles/PMC49517/ https://ncbi.nlm.nih.gov/pubmed/1631141 https://ncbi.nlm.nih.gov/pmc/articles/PMC49518/ https://ncbi.nlm.nih.gov/pubmed/1631142 https://ncbi.nlm.nih.gov/pmc/articles/PMC49519/ https://ncbi.nlm.nih.gov/pubmed/1321440 https://ncbi.nlm.nih.gov/pmc/articles/PMC49520/ https://ncbi.nlm.nih.gov/pubmed/1631143 https://ncbi.nlm.nih.gov/pmc/articles/PMC49521/ https://ncbi.nlm.nih.gov/pubmed/1321441 https://ncbi.nlm.nih.gov/pmc/articles/PMC49522/ https://ncbi.nlm.nih.gov/pubmed/1378628 https://ncbi.nlm.nih.gov/pmc/articles/PMC49523/ https://ncbi.nlm.nih.gov/pubmed/1631144 https://ncbi.nlm.nih.gov/pmc/articles/PMC49524/ https://ncbi.nlm.nih.gov/pubmed/1631145 https://ncbi.nlm.nih.gov/pmc/articles/PMC49525/ https://ncbi.nlm.nih.gov/pubmed/1631146 https://ncbi.nlm.nih.gov/pmc/articles/PMC49526/ https://ncbi.nlm.nih.gov/pubmed/1631147 https://ncbi.nlm.nih.gov/pmc/articles/PMC49527/ https://ncbi.nlm.nih.gov/pubmed/1631148 https://ncbi.nlm.nih.gov/pmc/articles/PMC49528/ https://ncbi.nlm.nih.gov/pubmed/1321442 https://ncbi.nlm.nih.gov/pmc/articles/PMC49529/ https://ncbi.nlm.nih.gov/pubmed/1631149 https://ncbi.nlm.nih.gov/pmc/articles/PMC49530/ https://ncbi.nlm.nih.gov/pubmed/1378629 https://ncbi.nlm.nih.gov/pmc/articles/PMC49531/ https://ncbi.nlm.nih.gov/pubmed/1631150 https://ncbi.nlm.nih.gov/pmc/articles/PMC49532/ https://ncbi.nlm.nih.gov/pubmed/1631151 https://ncbi.nlm.nih.gov/pmc/articles/PMC49533/ https://ncbi.nlm.nih.gov/pubmed/1631152 https://ncbi.nlm.nih.gov/pmc/articles/PMC49534/ https://ncbi.nlm.nih.gov/pubmed/1631153 https://ncbi.nlm.nih.gov/pmc/articles/PMC49535/ https://ncbi.nlm.nih.gov/pubmed/1631154 https://ncbi.nlm.nih.gov/pmc/articles/PMC49536/ https://ncbi.nlm.nih.gov/pubmed/1631155 https://ncbi.nlm.nih.gov/pmc/articles/PMC49537/ https://ncbi.nlm.nih.gov/pubmed/1378630 https://ncbi.nlm.nih.gov/pmc/articles/PMC49538/ https://ncbi.nlm.nih.gov/pubmed/1631156 https://ncbi.nlm.nih.gov/pmc/articles/PMC49539/ https://ncbi.nlm.nih.gov/pubmed/1378631 https://ncbi.nlm.nih.gov/pmc/articles/PMC49540/ https://ncbi.nlm.nih.gov/pubmed/1385875 https://ncbi.nlm.nih.gov/pmc/articles/PMC49541/ https://ncbi.nlm.nih.gov/pubmed/1321443 https://ncbi.nlm.nih.gov/pmc/articles/PMC49542/ https://ncbi.nlm.nih.gov/pubmed/1631157 https://ncbi.nlm.nih.gov/pmc/articles/PMC49543/ https://ncbi.nlm.nih.gov/pubmed/1321444 https://ncbi.nlm.nih.gov/pmc/articles/PMC49544/ https://ncbi.nlm.nih.gov/pubmed/1631158 https://ncbi.nlm.nih.gov/pmc/articles/PMC49545/ https://ncbi.nlm.nih.gov/pubmed/1631159 https://ncbi.nlm.nih.gov/pmc/articles/PMC49546/ https://ncbi.nlm.nih.gov/pubmed/1631160 https://ncbi.nlm.nih.gov/pmc/articles/PMC49547/ https://ncbi.nlm.nih.gov/pubmed/11607305 https://ncbi.nlm.nih.gov/pmc/articles/PMC49548/ https://ncbi.nlm.nih.gov/pubmed/1631161 https://ncbi.nlm.nih.gov/pmc/articles/PMC49549/ https://ncbi.nlm.nih.gov/pubmed/1631162 https://ncbi.nlm.nih.gov/pmc/articles/PMC49550/ https://ncbi.nlm.nih.gov/pubmed/11607306 https://ncbi.nlm.nih.gov/pmc/articles/PMC49551/ https://ncbi.nlm.nih.gov/pubmed/1631163 https://ncbi.nlm.nih.gov/pmc/articles/PMC49552/ https://ncbi.nlm.nih.gov/pubmed/1631164 https://ncbi.nlm.nih.gov/pmc/articles/PMC49553/ https://ncbi.nlm.nih.gov/pubmed/1385876 https://ncbi.nlm.nih.gov/pmc/articles/PMC49554/ https://ncbi.nlm.nih.gov/pubmed/11607307 https://ncbi.nlm.nih.gov/pmc/articles/PMC49555/ https://ncbi.nlm.nih.gov/pubmed/1631165 https://ncbi.nlm.nih.gov/pmc/articles/PMC49556/ https://ncbi.nlm.nih.gov/pubmed/1631166 https://ncbi.nlm.nih.gov/pmc/articles/PMC49557/ https://ncbi.nlm.nih.gov/pubmed/1631167 https://ncbi.nlm.nih.gov/pmc/articles/PMC49558/ https://ncbi.nlm.nih.gov/pubmed/1631168 https://ncbi.nlm.nih.gov/pmc/articles/PMC49559/ https://ncbi.nlm.nih.gov/pubmed/1378632 https://ncbi.nlm.nih.gov/pmc/articles/PMC49560/ https://ncbi.nlm.nih.gov/pubmed/1321445
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Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein.

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