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NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice
PURPOSE: The active form of small GTPase RAC1 is required for activation of NADPH oxidase (NOX), which in turn generates reactive oxygen species (ROS) in nonphagocytic cells. We explored whether NOX-induced oxidative stress contributes to rod degeneration in retinas expressing constitutively active...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
The Association for Research in Vision and Ophthalmology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5113981/ https://ncbi.nlm.nih.gov/pubmed/27233035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-18974 |
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