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Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies
A major goal for HIV-1 vaccine development is an ability to elicit strong and durable broadly neutralizing antibody (bNAb) responses. The trimeric envelope glycoprotein (Env) spikes on HIV-1 are known to contain multiple epitopes that are susceptible to bNAbs isolated from infected individuals. None...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5217686/ https://ncbi.nlm.nih.gov/pubmed/27879316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.725614 |
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