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Anti‐inflammatory effects of infliximab in mice are independent of tumour necrosis factor α neutralization

Infliximab (IFX) has been used repeatedly in mouse preclinical models with associated claims that anti‐inflammatory effects are due to inhibition of mouse tumour necrosis factor (TNF)‐α. However, the mechanism of action in mice remains unclear. In this study, the binding specificity of IFX for mouse...

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Detalhes bibliográficos
Formato: Artigo
Idioma:en
Publicado em: John Wiley and Sons Inc. 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217947/
https://ncbi.nlm.nih.gov/pubmed/27669117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12872
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