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Activation of naïve CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling

Although there was no impairment in IL-2 secretion and proliferation of Fyn-deficient naïve CD4 cells after stimulation with antigen and antigen-presenting cells, stimulation of these cells with anti-CD3 and anti-CD28 revealed profound defects. Crosslinking of purified wild-type naïve CD4 cells with...

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Detalhes bibliográficos
Main Authors: Sugie, Katsuji, Jeon, Myung-Shin, Grey, Howard M.
Formato: Artigo
Idioma:English
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC522036/
https://ncbi.nlm.nih.gov/pubmed/15465914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406168101
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