Prodrugs of bisthiazolium salts are orally potent antimalarials

We created neutral antimalarial prodrugs that deliver bisthiazolium compounds with antimalarial activity in the nanomolar range. These drugs primarily affect early intraerythrocytic stages through rapid, nonreversible cytotoxicity. The compounds are suitable for both parenteral and oral use and plas...

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Autors principals: Vial, Henri J., Wein, Sharon, Farenc, Christine, Kocken, Clemens, Nicolas, Olivier, Ancelin, Marie Laure, Bressolle, Francoise, Thomas, Alan, Calas, Michèle
Format: Article
Idioma:English
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC523447/
https://ncbi.nlm.nih.gov/pubmed/15492221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404037101
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https://ncbi.nlm.nih.gov/pmc/articles/PMC523447/
https://ncbi.nlm.nih.gov/pubmed/15492221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404037101

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