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Chemical carcinogenesis: too many rodent carcinogens.

The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proporti...

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Detalhes bibliográficos
Main Authors:	Ames, B N, Gold, L S, Profet, M, Hope, T J, Huang, X J, McDonald, D, Parslow, T G, Protti, M P, Manfredi, A A, Straub, C, Howard, J F, Conti-Tronconi, B M, Whittemore, L A, Maniatis, T, Monck, J R, Alvarez de Toledo, G, Fernandez, J M, Das, O P, Levi-Minzi, S, Koury, M, Benner, M, Messing, J, Maeda, T, Mochizuki, N, Yamamoto, M, Zhang, J, Wu, S Y, Bertl, A, Slayman, C L, Yoshida, K, Matsuoka, M, Usuda, S, Mori, A, Ishizaka, K, Sakano, H, Hallaq, H, Sellmayer, A, Smith, T W, Leaf, A, Jerse, A E, Yu, J, Tall, B D, Kaper, J B, Mochida, S, Poulain, B, Eisel, U, Binz, T, Kurazono, H, Niemann, H, Tauc, L, Pauling, L, Pons, F, Augier, N, Heilig, R, Léger, J, Mornet, D, Léger, J J, Tjoelker, L W, Carlson, L M, Lee, K, Lahti, J, McCormack, W T, Leiden, J M, Chen, C L, Cooper, M D, Thompson, C B, Hazan, U, Thomas, D, Alcami, J, Bachelerie, F, Israel, N, Yssel, H, Virelizier, J L, Arenzana-Seisdedos, F, Ris-Stalpers, C, Kuiper, G G, Faber, P W, Schweikert, H U, van Rooij, H C, Zegers, N D, Hodgins, M B, Degenhart, H J, Trapman, J, Brinkmann, A O, Făgărăsan, M O, Aiello, F, Muegge, K, Durum, S, Axelrod, J, Ne'eman, Y, Sternberg, S, Corthésy, B, Claret, F X, Wahli, W, Varlet, I, Radman, M, Brooks, P, Nagarajan, V, Parson, W W, Gaul, D, Schenck, C, Oiwa, K, Chaen, S, Kamitsubo, E, Shimmen, T, Sugi, H, Waddell, T, Cohen, A, Lingwood, C A, Ruyle, M, Connor, W E, Anderson, G J, Lowensohn, R I, Yang, P M, Olsen, N J, Siminovitch, K A, Olee, T, Kozin, F, Carson, D A, Chen, P P, Shoyab, M, McDonald, V L, Byles, C, Todaro, G J, Plowman, G D, Geibel, J, Giebisch, G, Boron, W F, Karle, I L, Flippen-Anderson, J L, Uma, K, Balaram, P, Satoh, T, Endo, M, Nakafuku, M, Akiyama, T, Yamamoto, T, Kaziro, Y, Yip, W K, Dong, J G, Kenny, J W, Thompson, G A, Yang, S F, Itohara, S, Tonegawa, S, Micanovic, R, Kodukula, K, Gerber, L D, Udenfriend, S, Price, D J, Gunsalus, J R, Avruch, J, Sauer, N, Caspari, T, Klebl, F, Tanner, W, Cutting, A E, Höög, C, Calzone, F J, Britten, R J, Davidson, E H, Rouault, T A, Tang, C K, Kaptain, S, Burgess, W H, Haile, D J, Samaniego, F, McBride, O W, Harford, J B, Klausner, R D, Tsai, C H, Williams, M V, Glaser, R, Pette, M, Fujita, K, Wilkinson, D, Altmann, D M, Trowsdale, J, Giegerich, G, Hinkkanen, A, Epplen, J T, Kappos, L, Wekerle, H, Gautam, N, Northup, J, Tamir, H, Simon, M I, Kleiber, J, Kalousek, F, Swaroop, M, Rosenberg, L E, Talon, M, Koornneef, M, Zeevaart, J A, Choi, J, Costa, M L, Mermelstein, C S, Chagas, C, Holtzer, S, Holtzer, H, Sigmund, C D, Jones, C A, Mullins, J J, Kim, U, Gross, K W, Valgeirsdóttir, K, Traverse, K L, Pardue, M L, Bridges, R S, Numan, M, Ronsheim, P M, Mann, P E, Lupini, C E, Huang, Y K, Kung, H F, Kamata, T
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC54830/ https://ncbi.nlm.nih.gov/pubmed/2217209 https://ncbi.nlm.nih.gov/pmc/articles/PMC54831/ https://ncbi.nlm.nih.gov/pubmed/2217210 https://ncbi.nlm.nih.gov/pmc/articles/PMC54832/ https://ncbi.nlm.nih.gov/pubmed/2217211 https://ncbi.nlm.nih.gov/pmc/articles/PMC54833/ https://ncbi.nlm.nih.gov/pubmed/2217212 https://ncbi.nlm.nih.gov/pmc/articles/PMC54834/ https://ncbi.nlm.nih.gov/pubmed/2145582 https://ncbi.nlm.nih.gov/pmc/articles/PMC54837/ https://ncbi.nlm.nih.gov/pubmed/2172963 https://ncbi.nlm.nih.gov/pmc/articles/PMC54838/ https://ncbi.nlm.nih.gov/pubmed/2235997 https://ncbi.nlm.nih.gov/pmc/articles/PMC54839/ https://ncbi.nlm.nih.gov/pubmed/2235998 https://ncbi.nlm.nih.gov/pmc/articles/PMC54840/ https://ncbi.nlm.nih.gov/pubmed/2172964 https://ncbi.nlm.nih.gov/pmc/articles/PMC54841/ https://ncbi.nlm.nih.gov/pubmed/2235999 https://ncbi.nlm.nih.gov/pmc/articles/PMC54842/ https://ncbi.nlm.nih.gov/pubmed/1700419 https://ncbi.nlm.nih.gov/pmc/articles/PMC54843/ https://ncbi.nlm.nih.gov/pubmed/2122447 https://ncbi.nlm.nih.gov/pmc/articles/PMC54844/ https://ncbi.nlm.nih.gov/pubmed/2172965 https://ncbi.nlm.nih.gov/pmc/articles/PMC54845/ https://ncbi.nlm.nih.gov/pubmed/2172966 https://ncbi.nlm.nih.gov/pmc/articles/PMC54846/ https://ncbi.nlm.nih.gov/pubmed/2236000 https://ncbi.nlm.nih.gov/pmc/articles/PMC54847/ https://ncbi.nlm.nih.gov/pubmed/11607108 https://ncbi.nlm.nih.gov/pmc/articles/PMC54848/ https://ncbi.nlm.nih.gov/pubmed/2236001 https://ncbi.nlm.nih.gov/pmc/articles/PMC54849/ https://ncbi.nlm.nih.gov/pubmed/2236002 https://ncbi.nlm.nih.gov/pmc/articles/PMC54850/ https://ncbi.nlm.nih.gov/pubmed/2146676 https://ncbi.nlm.nih.gov/pmc/articles/PMC54851/ https://ncbi.nlm.nih.gov/pubmed/2236003 https://ncbi.nlm.nih.gov/pmc/articles/PMC54852/ https://ncbi.nlm.nih.gov/pubmed/1978316 https://ncbi.nlm.nih.gov/pmc/articles/PMC54853/ https://ncbi.nlm.nih.gov/pubmed/11607109 https://ncbi.nlm.nih.gov/pmc/articles/PMC54854/ https://ncbi.nlm.nih.gov/pubmed/2236004 https://ncbi.nlm.nih.gov/pmc/articles/PMC54855/ https://ncbi.nlm.nih.gov/pubmed/2236005 https://ncbi.nlm.nih.gov/pmc/articles/PMC54856/ https://ncbi.nlm.nih.gov/pubmed/2236006 https://ncbi.nlm.nih.gov/pmc/articles/PMC54857/ https://ncbi.nlm.nih.gov/pubmed/2236007 https://ncbi.nlm.nih.gov/pmc/articles/PMC54858/ https://ncbi.nlm.nih.gov/pubmed/2236008 https://ncbi.nlm.nih.gov/pmc/articles/PMC54859/ https://ncbi.nlm.nih.gov/pubmed/2146677 https://ncbi.nlm.nih.gov/pmc/articles/PMC54860/ https://ncbi.nlm.nih.gov/pubmed/2122448 https://ncbi.nlm.nih.gov/pmc/articles/PMC54861/ https://ncbi.nlm.nih.gov/pubmed/2236009 https://ncbi.nlm.nih.gov/pmc/articles/PMC54862/ https://ncbi.nlm.nih.gov/pubmed/2172967 https://ncbi.nlm.nih.gov/pmc/articles/PMC54863/ https://ncbi.nlm.nih.gov/pubmed/2236010 https://ncbi.nlm.nih.gov/pmc/articles/PMC54864/ https://ncbi.nlm.nih.gov/pubmed/2146678 https://ncbi.nlm.nih.gov/pmc/articles/PMC54865/ https://ncbi.nlm.nih.gov/pubmed/2122449 https://ncbi.nlm.nih.gov/pmc/articles/PMC54866/ https://ncbi.nlm.nih.gov/pubmed/2236011 https://ncbi.nlm.nih.gov/pmc/articles/PMC54867/ https://ncbi.nlm.nih.gov/pubmed/1700420 https://ncbi.nlm.nih.gov/pmc/articles/PMC54868/ https://ncbi.nlm.nih.gov/pubmed/2122450 https://ncbi.nlm.nih.gov/pmc/articles/PMC54869/ https://ncbi.nlm.nih.gov/pubmed/11607110 https://ncbi.nlm.nih.gov/pmc/articles/PMC54870/ https://ncbi.nlm.nih.gov/pubmed/1700421 https://ncbi.nlm.nih.gov/pmc/articles/PMC54871/ https://ncbi.nlm.nih.gov/pubmed/2172968 https://ncbi.nlm.nih.gov/pmc/articles/PMC54872/ https://ncbi.nlm.nih.gov/pubmed/1700422 https://ncbi.nlm.nih.gov/pmc/articles/PMC54873/ https://ncbi.nlm.nih.gov/pubmed/1700423 https://ncbi.nlm.nih.gov/pmc/articles/PMC54874/ https://ncbi.nlm.nih.gov/pubmed/2122451 https://ncbi.nlm.nih.gov/pmc/articles/PMC54875/ https://ncbi.nlm.nih.gov/pubmed/2236012 https://ncbi.nlm.nih.gov/pmc/articles/PMC54876/ https://ncbi.nlm.nih.gov/pubmed/2236013 https://ncbi.nlm.nih.gov/pmc/articles/PMC54877/ https://ncbi.nlm.nih.gov/pubmed/2172969 https://ncbi.nlm.nih.gov/pmc/articles/PMC54878/ https://ncbi.nlm.nih.gov/pubmed/2172970 https://ncbi.nlm.nih.gov/pmc/articles/PMC54879/ https://ncbi.nlm.nih.gov/pubmed/2122452 https://ncbi.nlm.nih.gov/pmc/articles/PMC54880/ https://ncbi.nlm.nih.gov/pubmed/2236014 https://ncbi.nlm.nih.gov/pmc/articles/PMC54881/ https://ncbi.nlm.nih.gov/pubmed/2172971
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Chemical carcinogenesis: too many rodent carcinogens.

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