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A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin.
To kill human or primate cells expressing the p55 subunit of the interleukin 2 receptor, we have constructed a single-chain immunotoxin. DNA sequences encoding the first 388 amino acids of diphtheria toxin (DT) were fused to DNA elements encoding the antigen-binding portion (variable region or Fv) o...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | en |
| Publicado em: |
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC55192/ https://ncbi.nlm.nih.gov/pubmed/2251289 |
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