Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast

Genome integrity is monitored by a checkpoint that delays mitosis in response to DNA damage. This checkpoint is enforced by Chk1, a protein kinase that inhibits the mitotic inducer Cdc25. In fission yeast, Chk1 is regulated by a group of proteins that includes Rad3, a protein kinase related to human...

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Main Authors: Lopez-Girona, Antonia, Tanaka, Katsunori, Chen, Xiao-Bo, Baber, Beth A., McGowan, Clare H., Russell, Paul
Formato: Artigo
Idioma:en
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC58722/
https://ncbi.nlm.nih.gov/pubmed/11553781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191557598
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https://ncbi.nlm.nih.gov/pmc/articles/PMC58722/
https://ncbi.nlm.nih.gov/pubmed/11553781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191557598

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