Normal Hematopoiesis and Inflammatory Responses Despite Discrete Signaling Defects in Gα15 Knockout Mice

Gα15 activates phospholipase Cβ in response to the greatest variety of agonist-stimulated heptahelical receptors among the four Gq class G-protein α subunits expressed in mammals. Gα15 is primarily expressed in hematopoietic cells in fetal and adult mice. We disrupted the Gα15 gene by homologous rec...

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Main Authors: Davignon, I., Catalina, M. D., Smith, D., Montgomery, J., Swantek, J., Croy, J., Siegelman, M., Wilkie, T. M., Bai, Yidong, Shakeley, Rebecca M., Attardi, Giuseppe, Tang, Zhaohua, Kuo, Tiffany, Shen, Jenny, Lin, Ren-Jang, Keegan, Liam P., Gerber, André P., Brindle, Jim, Leemans, Ronny, Gallo, Angela, Keller, Walter, O'Connell, Mary A., Paran, Nir, Ori, Assaf, Haviv, Izhak, Shaul, Yosef, Lorincz, Matthew C., Schübeler, Dirk, Goeke, Scott C., Walters, Mark, Groudine, Mark, Martin, David I. K., Andoniou, Christopher E., Lill, Nancy L., Thien, Christine B., Lupher, Mark L., Ota, Satoshi, Bowtell, David D. L., Scaife, Robin M., Langdon, Wallace Y., Band, Hamid, Ramakrishnan, Meera, Liu, Wen-Man, DiCroce, Patricia A., Posner, Aleza, Zheng, Jian, Kohwi-Shigematsu, Terumi, Krontiris, Theodore G., Stubdal, Hilde, Lynch, Catherine A., Moriarty, Ann, Fang, Qing, Chickering, Troy, Deeds, James D., Fairchild-Huntress, Victoria, Charlat, Olga, Dunmore, Judy H., Kleyn, Patrick, Huszar, Dennis, Kapeller, Rosana, McManus, Michael T., Adler, Brian K., Pollard, Victoria W., Hajduk, Stephen L., Huang, Hoching L., Brandriss, Marjorie C., Ohneda, Kinuko, Mirmira, Raghavendra G., Wang, Juehu, Johnson, Jeffrey D., German, Michael S., Greenwel, Patricia, Tanaka, Shizuko, Penkov, Dmitri, Zhang, Wen, Olive, Michelle, Moll, Jonathan, Vinson, Charles, Di Liberto, Maurizio, Ramirez, Francesco, Mahajan, Shahana S., Wilson, Angus C., Eskes, Robert, Desagher, Solange, Antonsson, Bruno, Martinou, Jean-Claude, Merritt, Chris, Enslen, Hervé, Diehl, Nicole, Conze, Dietrich, Davis, Roger J., Rincón, Mercedes, Chen, Min, Cheng, Alan, Candotti, Fabio, Zhou, Yong-Jie, Hymel, Anka, Fasth, Anders, Notarangelo, Luigi D., O'Shea, John J., Lin, Bingzhen, Chen, Guo-quan, Xiao, Dongmei, Kolluri, Siva Kumar, Cao, Xihua, Su, Hong, Zhang, Xiao-kun, Davis, Dana, Wilson, R. Bryce, Mitchell, Aaron P., Ong, S. H., Guy, G. R., Hadari, Y. R., Laks, S., Gotoh, N., Schlessinger, J., Lax, I., Faruqi, A. Fawad, Datta, Hirock J., Carroll, Dana, Seidman, Michael M., Glazer, Peter M., Jackson, Mark W., Berberich, Steven J., Reusch, Jane E. B., Colton, Lilliester A., Klemm, Dwight J., Yan, Zhen, Fedorov, Sergei A., Mumby, Marc C., Williams, R. Sanders, Kelkar, Nyaya, Gupta, Shashi, Dickens, Martin, Inbal, Boaz, Shani, Gidi, Cohen, Ofer, Kissil, Joseph L., Kimchi, Adi, Hirsch, Emilio, Oohashi, Toshitaka, Ahmad, Marianne, Stamm, Stefan, Fässler, Reinhard, Liu, Hong-Xiang, Chew, Shern L., Cartegni, Luca, Zhang, Michael Q., Krainer, Adrian R., Lehembre, François, Badenhorst, Paul, Müller, Stefan, Travers, Andrew, Schweisguth, François, Dejean, Anne, Nollen, Ellen A. A., Brunsting, Jeanette F., Song, Jaewhan, Kampinga, Harm H., Morimoto, Richard I., Niedermeyer, J., Kriz, M., Hilberg, F., Garin-Chesa, P., Bamberger, U., Lenter, M. C., Park, J., Viertel, B., Püschner, H., Mauz, M., Rettig, W. J., Schnapp, A., Lopinski, John D., Dinman, Jonathan D., Bruenn, Jeremy A., Lamontagne, Bruno, Tremblay, Annie, Elela, Sherif Abou, Trebitsh, Tova, Levitan, Alex, Sofer, Anat, Danon, Avihai, Johansson, Lotta, Båvner, Ann, Thomsen, Jane S., Färnegårdh, MatHias, Gustafsson, Jan-Åke, Treuter, Eckardt, Dunphy, Elizabeth L., Johnson, Theron, Auerbach, Scott S., Wang, Edith H., Kim, Dae-Won, Cochran, Brent H., Hao, Sheryl X., Ren, Ruibao, Stoneley, Mark, Chappell, Stephen A., Jopling, Catherine L., MacFarlane, Marion, Willis, Anne E., O'Mahony, Alison, Lin, Xin, Geleziunas, Romas, Greene, Warner C., Reimerink, Johan H. J., van der Avoort, Harrie G. A. M., van Loon, Anton M., Koopmans, Marion P. G., Janda, J. Michael, Abbott, Sharon L., Albert, M. John, Neshat, Mehran S., Raitano, Arthur B., Wang, Hong-Gang, Reed, John C., Sawyers, Charles L., Tondella, Maria Lucia C., Reeves, Mike W., Popovic, Tanja, Rosenstein, Nancy, Holloway, Brian P., Mayer, Leonard W., Cartwright, Charles P., Tjitra, Emiliana, Suprianto, Sri, Dyer, Mary, Currie, Bart J., Anstey, Nicholas M., Koehler, Carla M., Murphy, Michael P., Bally, Nikolaus A., Leuenberger, Danielle, Oppliger, Wolfgang, Dolfini, Luisita, Junne, Tina, Schatz, Gottfried, Or, Eran, McDonough, Patrick L., Fogelman, David, Shin, Sang J., Brunner, Michael A., Lein, Donald H., Bärtsch, Stephan, Kang, Leslie E., Symington, Lorraine S., Kirstein, Lynn M., Mellors, John W., Rinaldo, Charles R., Margolick, Joseph B., Giorgi, Janis V., Phair, John P., Dietz, Edith, Gupta, Phalguni, Sherlock, Christopher H., Hogg, Robert, Montaner, J. S. G., Muñoz, Alvaro
Formato: Artigo
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Publicado em: American Society for Microbiology 2000
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Gene Expression
Transcriptional Regulation
Cell Growth and Development
DNA Dynamics and Chromosome Structure
Virology
Bacteriology
Parasitology
Cell and Organelle Structure and Assembly
Clinical Veterinary Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC85196/
https://ncbi.nlm.nih.gov/pubmed/10629036
https://ncbi.nlm.nih.gov/pmc/articles/PMC85197/
https://ncbi.nlm.nih.gov/pubmed/10629037
https://ncbi.nlm.nih.gov/pmc/articles/PMC85198/
https://ncbi.nlm.nih.gov/pubmed/10629038
https://ncbi.nlm.nih.gov/pmc/articles/PMC85199/
https://ncbi.nlm.nih.gov/pubmed/10629039
https://ncbi.nlm.nih.gov/pmc/articles/PMC85200/
https://ncbi.nlm.nih.gov/pubmed/10629040
https://ncbi.nlm.nih.gov/pmc/articles/PMC85201/
https://ncbi.nlm.nih.gov/pubmed/10629041
https://ncbi.nlm.nih.gov/pmc/articles/PMC85202/
https://ncbi.nlm.nih.gov/pubmed/10629042
https://ncbi.nlm.nih.gov/pmc/articles/PMC85203/
https://ncbi.nlm.nih.gov/pubmed/10629043
https://ncbi.nlm.nih.gov/pmc/articles/PMC85204/
https://ncbi.nlm.nih.gov/pubmed/10629044
https://ncbi.nlm.nih.gov/pmc/articles/PMC85205/
https://ncbi.nlm.nih.gov/pubmed/10629045
https://ncbi.nlm.nih.gov/pmc/articles/PMC85206/
https://ncbi.nlm.nih.gov/pubmed/10629046
https://ncbi.nlm.nih.gov/pmc/articles/PMC85207/
https://ncbi.nlm.nih.gov/pubmed/10629047
https://ncbi.nlm.nih.gov/pmc/articles/PMC85208/
https://ncbi.nlm.nih.gov/pubmed/10629048
https://ncbi.nlm.nih.gov/pmc/articles/PMC85209/
https://ncbi.nlm.nih.gov/pubmed/10629049
https://ncbi.nlm.nih.gov/pmc/articles/PMC85210/
https://ncbi.nlm.nih.gov/pubmed/10629050
https://ncbi.nlm.nih.gov/pmc/articles/PMC85211/
https://ncbi.nlm.nih.gov/pubmed/10629051
https://ncbi.nlm.nih.gov/pmc/articles/PMC85212/
https://ncbi.nlm.nih.gov/pubmed/10629052
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https://ncbi.nlm.nih.gov/pmc/articles/PMC85241/
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https://ncbi.nlm.nih.gov/pubmed/10648604
https://ncbi.nlm.nih.gov/pmc/articles/PMC85243/
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https://ncbi.nlm.nih.gov/pmc/articles/PMC85244/
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https://ncbi.nlm.nih.gov/pmc/articles/PMC85196/
https://ncbi.nlm.nih.gov/pubmed/10629036
https://ncbi.nlm.nih.gov/pmc/articles/PMC85197/
https://ncbi.nlm.nih.gov/pubmed/10629037
https://ncbi.nlm.nih.gov/pmc/articles/PMC85198/
https://ncbi.nlm.nih.gov/pubmed/10629038
https://ncbi.nlm.nih.gov/pmc/articles/PMC85199/
https://ncbi.nlm.nih.gov/pubmed/10629039
https://ncbi.nlm.nih.gov/pmc/articles/PMC85200/
https://ncbi.nlm.nih.gov/pubmed/10629040
https://ncbi.nlm.nih.gov/pmc/articles/PMC85201/
https://ncbi.nlm.nih.gov/pubmed/10629041
https://ncbi.nlm.nih.gov/pmc/articles/PMC85202/
https://ncbi.nlm.nih.gov/pubmed/10629042
https://ncbi.nlm.nih.gov/pmc/articles/PMC85203/
https://ncbi.nlm.nih.gov/pubmed/10629043
https://ncbi.nlm.nih.gov/pmc/articles/PMC85204/
https://ncbi.nlm.nih.gov/pubmed/10629044
https://ncbi.nlm.nih.gov/pmc/articles/PMC85205/
https://ncbi.nlm.nih.gov/pubmed/10629045
https://ncbi.nlm.nih.gov/pmc/articles/PMC85206/
https://ncbi.nlm.nih.gov/pubmed/10629046
https://ncbi.nlm.nih.gov/pmc/articles/PMC85207/
https://ncbi.nlm.nih.gov/pubmed/10629047
https://ncbi.nlm.nih.gov/pmc/articles/PMC85208/
https://ncbi.nlm.nih.gov/pubmed/10629048
https://ncbi.nlm.nih.gov/pmc/articles/PMC85209/
https://ncbi.nlm.nih.gov/pubmed/10629049
https://ncbi.nlm.nih.gov/pmc/articles/PMC85210/
https://ncbi.nlm.nih.gov/pubmed/10629050
https://ncbi.nlm.nih.gov/pmc/articles/PMC85211/
https://ncbi.nlm.nih.gov/pubmed/10629051
https://ncbi.nlm.nih.gov/pmc/articles/PMC85212/
https://ncbi.nlm.nih.gov/pubmed/10629052
https://ncbi.nlm.nih.gov/pmc/articles/PMC85213/
https://ncbi.nlm.nih.gov/pubmed/10629053
https://ncbi.nlm.nih.gov/pmc/articles/PMC85214/
https://ncbi.nlm.nih.gov/pubmed/10629054
https://ncbi.nlm.nih.gov/pmc/articles/PMC85215/
https://ncbi.nlm.nih.gov/pubmed/10629055
https://ncbi.nlm.nih.gov/pmc/articles/PMC85216/
https://ncbi.nlm.nih.gov/pubmed/10629056
https://ncbi.nlm.nih.gov/pmc/articles/PMC85217/
https://ncbi.nlm.nih.gov/pubmed/10629057
https://ncbi.nlm.nih.gov/pmc/articles/PMC85218/
https://ncbi.nlm.nih.gov/pubmed/10629058
https://ncbi.nlm.nih.gov/pmc/articles/PMC85219/
https://ncbi.nlm.nih.gov/pubmed/10629059
https://ncbi.nlm.nih.gov/pmc/articles/PMC85220/
https://ncbi.nlm.nih.gov/pubmed/10629060
https://ncbi.nlm.nih.gov/pmc/articles/PMC85221/
https://ncbi.nlm.nih.gov/pubmed/10629061
https://ncbi.nlm.nih.gov/pmc/articles/PMC85222/
https://ncbi.nlm.nih.gov/pubmed/10629062
https://ncbi.nlm.nih.gov/pmc/articles/PMC85223/
https://ncbi.nlm.nih.gov/pubmed/10629063
https://ncbi.nlm.nih.gov/pmc/articles/PMC85224/
https://ncbi.nlm.nih.gov/pubmed/10629064
https://ncbi.nlm.nih.gov/pmc/articles/PMC85225/
https://ncbi.nlm.nih.gov/pubmed/10629065
https://ncbi.nlm.nih.gov/pmc/articles/PMC85226/
https://ncbi.nlm.nih.gov/pubmed/10629066
https://ncbi.nlm.nih.gov/pmc/articles/PMC85227/
https://ncbi.nlm.nih.gov/pubmed/10648594
https://ncbi.nlm.nih.gov/pmc/articles/PMC85228/
https://ncbi.nlm.nih.gov/pubmed/10648595
https://ncbi.nlm.nih.gov/pmc/articles/PMC85229/
https://ncbi.nlm.nih.gov/pubmed/10648596
https://ncbi.nlm.nih.gov/pmc/articles/PMC85230/
https://ncbi.nlm.nih.gov/pubmed/10648597
https://ncbi.nlm.nih.gov/pmc/articles/PMC85231/
https://ncbi.nlm.nih.gov/pubmed/10648598
https://ncbi.nlm.nih.gov/pmc/articles/PMC85232/
https://ncbi.nlm.nih.gov/pubmed/10648599
https://ncbi.nlm.nih.gov/pmc/articles/PMC85233/
https://ncbi.nlm.nih.gov/pubmed/10648600
https://ncbi.nlm.nih.gov/pmc/articles/PMC85234/
https://ncbi.nlm.nih.gov/pubmed/10648601
https://ncbi.nlm.nih.gov/pmc/articles/PMC85235/
https://ncbi.nlm.nih.gov/pubmed/10648602
https://ncbi.nlm.nih.gov/pmc/articles/PMC85236/
https://ncbi.nlm.nih.gov/pubmed/10405373
https://ncbi.nlm.nih.gov/pmc/articles/PMC85237/
https://ncbi.nlm.nih.gov/pubmed/10405374
https://ncbi.nlm.nih.gov/pmc/articles/PMC85238/
https://ncbi.nlm.nih.gov/pubmed/10648603
https://ncbi.nlm.nih.gov/pmc/articles/PMC85239/
https://ncbi.nlm.nih.gov/pubmed/10405375
https://ncbi.nlm.nih.gov/pmc/articles/PMC85240/
https://ncbi.nlm.nih.gov/pubmed/10405376
https://ncbi.nlm.nih.gov/pmc/articles/PMC85241/
https://ncbi.nlm.nih.gov/pubmed/10405377
https://ncbi.nlm.nih.gov/pmc/articles/PMC85242/
https://ncbi.nlm.nih.gov/pubmed/10648604
https://ncbi.nlm.nih.gov/pmc/articles/PMC85243/
https://ncbi.nlm.nih.gov/pubmed/10405378
https://ncbi.nlm.nih.gov/pmc/articles/PMC85244/
https://ncbi.nlm.nih.gov/pubmed/10648605
https://ncbi.nlm.nih.gov/pmc/articles/PMC85245/
https://ncbi.nlm.nih.gov/pubmed/10405379

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