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SSeCKS, a Major Protein Kinase C Substrate with Tumor Suppressor Activity, Regulates G(1)→S Progression by Controlling the Expression and Cellular Compartmentalization of Cyclin D
SSeCKS, first isolated as a G(1)→S inhibitor that is downregulated in src- and ras-transformed cells, is a major cytoskeleton-associated PKC substrate with tumor suppressor and kinase-scaffolding activities. Previous attempts at constitutive expression resulted in cell variants with truncated ectopi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | en |
| Publicado em: |
American Society for Microbiology
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC86280/ https://ncbi.nlm.nih.gov/pubmed/10982843 |
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