Pentamidine Inhibition of Group I Intron Splicing in Candida albicans Correlates with Growth Inhibition

We previously demonstrated that pentamidine, which has been clinically used against Pneumocystis carinii, inhibits in vitro a group I intron ribozyme from that organism. Another fungal pathogen, Candida albicans, also harbors a group I intron ribozyme (Ca.LSU) in the essential rRNA genes in almost h...

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Main Authors: Miletti, Karl E., Leibowitz, Michael J., Portillo, Aránzazu, Ruiz-Larrea, Fernanda, Zarazaga, Myriam, Alonso, Ana, Martinez, Jose Luis, Torres, Carmen, Newton, Paul, Suputtamongkol, Yupin, Teja-Isavadharm, Paktiya, Pukrittayakamee, Sasithon, Navaratnam, V, Bates, Imelda, White, Nicholas, Brophy, Donald F., Israel, Debra S., Pastor, Antonio, Gillotin, Catherine, Chittick, Greg E., Symonds, William T., Lou, Yu, Sadler, Brian M., Polk, Ron E., Conte, John E., Golden, Jeffrey A., McQuitty, Mari, Kipps, Juliana, Lin, Emil T., Zurlinden, Elisabeth, Nzila, A. M., Mberu, E. K., Sulo, J., Dayo, H., Winstanley, P. A., Sibley, C. H., Watkins, W. M., Silva, J., Aguilar, C., Ayala, G., Estrada, M. A., Garza-Ramos, U., Lara-Lemus, R., Ledezma, L., Kaye, Keith S., Harris, Anthony D., Gold, Howard, Carmeli, Yehuda, Wang, Erjian, Simard, Marie, Bergeron, Yves, Beauchamp, Denis, Bergeron, Michel G., Brophy, Victoria Hertle, Vasquez, John, Nelson, Richard G., Forney, John R., Rosowsky, Andre, Sibley, Carol Hopkins, Fletcher, Courtney V., Brundage, Richard C., Remmel, Rory P., Page, Linda M., Weller, Dennis, Calles, Nancy R., Simon, Cara, Kline, Mark W., Appleman, Maria D., Belzberg, Howard, Citron, Diane M., Heseltine, Peter N. R., Yellin, Albert E., Murray, James, Berne, Thomas V., Hughes, Walter T., Shenep, Jerry L., Rodman, John H., Fridland, Arnold, Willoughby, Rodney, Blanchard, Suzette, Purdue, Lynette, Coakley, Dion F., Cundy, Kenneth C., Culnane, Mary, Zimmer, Bonnie, Burchett, Sandra, Read, Jennifer S., Jiang, Lei, Lee, Pei-Chieh, White, John, Rathod, Pradipsinh K., Snyder, Stuart, D'Argenio, D. Z., Weislow, Owen, Bilello, John A., Drusano, G. L., Pfeil, Esther, Wiedemann, Bernd, Rybak, Michael J., Hershberger, Ellie, Moldovan, Tabitha, Grucz, Richard G., Krakauer, Teresa, Choury, Daniele, Szajnert, Marie-France, Joly-Guillou, Marie-Laure, Azibi, Kemal, Delpech, Marc, Paul, Gérard, Heep, Markus, Rieger, Ulrich, Beck, Daniela, Lehn, Norbert, Ono, Tsuneko, Shiota, Sumiko, Hirota, Katsuhiko, Nemoto, Ken, Tsuchiya, Tomofusa, Miyake, Yoichiro, Yuan, Meifang, Hall, Lucinda M. C., Savelkoul, Paul H. M., Vandenbroucke-Grauls, Christina M. J. E., Livermore, David M., Hoellman, Dianne B., Pankuch, Glenn A., Jacobs, Michael R., Appelbaum, Peter C., Zhanel, George G., Karlowsky, James A., Harding, Godfrey K. M., Carrie, Anita, Mazzulli, Tony, Low, Donald E., Hoban, Daryl J., Veyries, Marie-Laure, Faurisson, Francois, Rouveix, Bernard, Endy, Drew, Yin, John, Warren, Katherine E., McCully, Cynthia M., Walsh, Thomas J., Balis, Frank M., Milatovic, Dana, Schmitz, Franz-Josef, Brisse, Sylvain, Verhoef, Jan, Fluit, Ad C., Ernst, Erika J., Klepser, Michael E., Pfaller, Michael A., Strigl, Sebastian, Roblin, Patricia M., Reznik, Tamara, Hammerschlag, Margaret R., Shultz, T. R., Tapsall, J. W., White, P. A., Newton, P. J., Gallicano, Keith, Kashuba, Angela D. M., Dyer, John R., Kramer, Linda M., Raasch, Ralph H., Eron, Joseph J., Cohen, Myron S., McNicholas, Paul M., Najarian, David J., Mann, Paul A., Hesk, David, Hare, Roberta S., Shaw, Karen J., Black, Todd A., Richard, Nathalie, Salomon, Horacio, Rando, Robert, Mansour, Tarek, Bowlin, Terry L., Wainberg, Mark A., Martínez, Miguel-Angel, Cabana, Marta, Parera, Mariona, Gutierrez, Arantxa, Esté, José A., Clotet, Bonaventura, Prats, Guillermo, Mirelis, Beatriz, Llovet, Teresa, Muñoz, Carmen, Miró, Elisenda, Navarro, Ferran, Wyde, Philip R., Moore-Poveda, Donna K., De Clercq, Erik, Neyts, Johan, Matsuda, Akira, Minakawa, Noriaki, Guzman, Efrain, Gilbert, Brian E., Aeschlimann, Jeffrey R., Al-Abdely, Hail M., Najvar, Laura, Bocanegra, Rosie, Fothergill, Annette, Loebenberg, David, Rinaldi, Michael G., Graybill, John R., Schaad, U. B., Bühlmann, U., Burger, R., Ruedeberg, A., Wilder-Smith, A., Rutishauser, M., Sennhauser, F., Herzog, C., Zellmeyer, M., Glück, R., Zarrouk, Virginie, Bozdogan, Bülent, Leclercq, Roland, Garry, Louis, Carbon, Claude, Fantin, Bruno, Stock, Stephen D., Hama, Hiroko, Radding, Jeffrey A., Young, Debra A., Takemoto, Jon Y., Vollmer, Waldemar, Höltje, Joachim-Volker, Maga, Giovanni, Ubiali, Daniela, Salvetti, Raul, Pregnolato, Massimo, Spadari, Silvio, Bradley, John S., Kearns, Gregory L., Reed, Michael D., Capparelli, Edmund V., Vincent, John, Wu, Tao, Wright, Katherine, Hurst, Steven F., Morrison, Christine J., Perea, Sofia, Pennick, Gennethel J., Modak, Asha, Fothergill, Annette W., Sutton, Deanna A., Sheehan, Daniel J., Steffensky, Marion, Mühlenweg, Agnes, Wang, Zhao-Xin, Li, Shu-Ming, Heide, Lutz
Formato: Artigo
Idioma:English
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Publicado em: American Society for Microbiology 2000
Assuntos:
Mechanisms of Action: Physiological Effects
Mechanisms of Resistance
Pharmacology
Experimental Therapeutics
Susceptibility
Antiviral Agents
Recent U.S. Food and Drug Administration Approvals
Letters to the Editor
Author's Correction
Analytical Procedures
Chemistry; Biosynthesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89798/
https://ncbi.nlm.nih.gov/pubmed/10722497
https://ncbi.nlm.nih.gov/pmc/articles/PMC89799/
https://ncbi.nlm.nih.gov/pubmed/10722498
https://ncbi.nlm.nih.gov/pmc/articles/PMC89800/
https://ncbi.nlm.nih.gov/pubmed/10722499
https://ncbi.nlm.nih.gov/pmc/articles/PMC89801/
https://ncbi.nlm.nih.gov/pubmed/10722500
https://ncbi.nlm.nih.gov/pmc/articles/PMC89802/
https://ncbi.nlm.nih.gov/pubmed/10722501
https://ncbi.nlm.nih.gov/pmc/articles/PMC89803/
https://ncbi.nlm.nih.gov/pubmed/10722502
https://ncbi.nlm.nih.gov/pmc/articles/PMC89804/
https://ncbi.nlm.nih.gov/pubmed/10722503
https://ncbi.nlm.nih.gov/pmc/articles/PMC89805/
https://ncbi.nlm.nih.gov/pubmed/10722504
https://ncbi.nlm.nih.gov/pmc/articles/PMC89806/
https://ncbi.nlm.nih.gov/pubmed/10722505
https://ncbi.nlm.nih.gov/pmc/articles/PMC89807/
https://ncbi.nlm.nih.gov/pubmed/10722506
https://ncbi.nlm.nih.gov/pmc/articles/PMC89808/
https://ncbi.nlm.nih.gov/pubmed/10722507
https://ncbi.nlm.nih.gov/pmc/articles/PMC89809/
https://ncbi.nlm.nih.gov/pubmed/10722508
https://ncbi.nlm.nih.gov/pmc/articles/PMC89810/
https://ncbi.nlm.nih.gov/pubmed/10722509
https://ncbi.nlm.nih.gov/pmc/articles/PMC89811/
https://ncbi.nlm.nih.gov/pubmed/10722510
https://ncbi.nlm.nih.gov/pmc/articles/PMC89812/
https://ncbi.nlm.nih.gov/pubmed/10722511
https://ncbi.nlm.nih.gov/pmc/articles/PMC89813/
https://ncbi.nlm.nih.gov/pubmed/10722512
https://ncbi.nlm.nih.gov/pmc/articles/PMC89814/
https://ncbi.nlm.nih.gov/pubmed/10722513
https://ncbi.nlm.nih.gov/pmc/articles/PMC89815/
https://ncbi.nlm.nih.gov/pubmed/10722514
https://ncbi.nlm.nih.gov/pmc/articles/PMC89816/
https://ncbi.nlm.nih.gov/pubmed/10722515
https://ncbi.nlm.nih.gov/pmc/articles/PMC89817/
https://ncbi.nlm.nih.gov/pubmed/10722516
https://ncbi.nlm.nih.gov/pmc/articles/PMC89818/
https://ncbi.nlm.nih.gov/pubmed/10722517
https://ncbi.nlm.nih.gov/pmc/articles/PMC89819/
https://ncbi.nlm.nih.gov/pubmed/10722518
https://ncbi.nlm.nih.gov/pmc/articles/PMC89820/
https://ncbi.nlm.nih.gov/pubmed/10722519
https://ncbi.nlm.nih.gov/pmc/articles/PMC89821/
https://ncbi.nlm.nih.gov/pubmed/10722520
https://ncbi.nlm.nih.gov/pmc/articles/PMC89822/
https://ncbi.nlm.nih.gov/pubmed/10722521
https://ncbi.nlm.nih.gov/pmc/articles/PMC89823/
https://ncbi.nlm.nih.gov/pubmed/10722522
https://ncbi.nlm.nih.gov/pmc/articles/PMC89824/
https://ncbi.nlm.nih.gov/pubmed/10722523
https://ncbi.nlm.nih.gov/pmc/articles/PMC89825/
https://ncbi.nlm.nih.gov/pubmed/10722524
https://ncbi.nlm.nih.gov/pmc/articles/PMC89826/
https://ncbi.nlm.nih.gov/pubmed/10722525
https://ncbi.nlm.nih.gov/pmc/articles/PMC89827/
https://ncbi.nlm.nih.gov/pubmed/10722526
https://ncbi.nlm.nih.gov/pmc/articles/PMC89828/
https://ncbi.nlm.nih.gov/pubmed/10722527
https://ncbi.nlm.nih.gov/pmc/articles/PMC89829/
https://ncbi.nlm.nih.gov/pubmed/10799008
https://ncbi.nlm.nih.gov/pmc/articles/PMC89830/
https://ncbi.nlm.nih.gov/pubmed/10799009
https://ncbi.nlm.nih.gov/pmc/articles/PMC89831/
https://ncbi.nlm.nih.gov/pmc/articles/PMC89832/
https://ncbi.nlm.nih.gov/pubmed/10770739
https://ncbi.nlm.nih.gov/pmc/articles/PMC89833/
https://ncbi.nlm.nih.gov/pubmed/10770740
https://ncbi.nlm.nih.gov/pmc/articles/PMC89834/
https://ncbi.nlm.nih.gov/pubmed/10770741
https://ncbi.nlm.nih.gov/pmc/articles/PMC89835/
https://ncbi.nlm.nih.gov/pubmed/10770742
https://ncbi.nlm.nih.gov/pmc/articles/PMC89836/
https://ncbi.nlm.nih.gov/pubmed/10770743
https://ncbi.nlm.nih.gov/pmc/articles/PMC89837/
https://ncbi.nlm.nih.gov/pubmed/10770744
https://ncbi.nlm.nih.gov/pmc/articles/PMC89838/
https://ncbi.nlm.nih.gov/pubmed/10770745
https://ncbi.nlm.nih.gov/pmc/articles/PMC89839/
https://ncbi.nlm.nih.gov/pubmed/10770746
https://ncbi.nlm.nih.gov/pmc/articles/PMC89840/
https://ncbi.nlm.nih.gov/pubmed/10770747
https://ncbi.nlm.nih.gov/pmc/articles/PMC89841/
https://ncbi.nlm.nih.gov/pubmed/10770748
https://ncbi.nlm.nih.gov/pmc/articles/PMC89842/
https://ncbi.nlm.nih.gov/pubmed/10770749
https://ncbi.nlm.nih.gov/pmc/articles/PMC89843/
https://ncbi.nlm.nih.gov/pubmed/10770750
https://ncbi.nlm.nih.gov/pmc/articles/PMC89844/
https://ncbi.nlm.nih.gov/pubmed/10770751
https://ncbi.nlm.nih.gov/pmc/articles/PMC89845/
https://ncbi.nlm.nih.gov/pubmed/10770752
https://ncbi.nlm.nih.gov/pmc/articles/PMC89846/
https://ncbi.nlm.nih.gov/pubmed/10770753
https://ncbi.nlm.nih.gov/pmc/articles/PMC89847/
https://ncbi.nlm.nih.gov/pubmed/10770754
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https://ncbi.nlm.nih.gov/pmc/articles/PMC89798/
https://ncbi.nlm.nih.gov/pubmed/10722497
https://ncbi.nlm.nih.gov/pmc/articles/PMC89799/
https://ncbi.nlm.nih.gov/pubmed/10722498
https://ncbi.nlm.nih.gov/pmc/articles/PMC89800/
https://ncbi.nlm.nih.gov/pubmed/10722499
https://ncbi.nlm.nih.gov/pmc/articles/PMC89801/
https://ncbi.nlm.nih.gov/pubmed/10722500
https://ncbi.nlm.nih.gov/pmc/articles/PMC89802/
https://ncbi.nlm.nih.gov/pubmed/10722501
https://ncbi.nlm.nih.gov/pmc/articles/PMC89803/
https://ncbi.nlm.nih.gov/pubmed/10722502
https://ncbi.nlm.nih.gov/pmc/articles/PMC89804/
https://ncbi.nlm.nih.gov/pubmed/10722503
https://ncbi.nlm.nih.gov/pmc/articles/PMC89805/
https://ncbi.nlm.nih.gov/pubmed/10722504
https://ncbi.nlm.nih.gov/pmc/articles/PMC89806/
https://ncbi.nlm.nih.gov/pubmed/10722505
https://ncbi.nlm.nih.gov/pmc/articles/PMC89807/
https://ncbi.nlm.nih.gov/pubmed/10722506
https://ncbi.nlm.nih.gov/pmc/articles/PMC89808/
https://ncbi.nlm.nih.gov/pubmed/10722507
https://ncbi.nlm.nih.gov/pmc/articles/PMC89809/
https://ncbi.nlm.nih.gov/pubmed/10722508
https://ncbi.nlm.nih.gov/pmc/articles/PMC89810/
https://ncbi.nlm.nih.gov/pubmed/10722509
https://ncbi.nlm.nih.gov/pmc/articles/PMC89811/
https://ncbi.nlm.nih.gov/pubmed/10722510
https://ncbi.nlm.nih.gov/pmc/articles/PMC89812/
https://ncbi.nlm.nih.gov/pubmed/10722511
https://ncbi.nlm.nih.gov/pmc/articles/PMC89813/
https://ncbi.nlm.nih.gov/pubmed/10722512
https://ncbi.nlm.nih.gov/pmc/articles/PMC89814/
https://ncbi.nlm.nih.gov/pubmed/10722513
https://ncbi.nlm.nih.gov/pmc/articles/PMC89815/
https://ncbi.nlm.nih.gov/pubmed/10722514
https://ncbi.nlm.nih.gov/pmc/articles/PMC89816/
https://ncbi.nlm.nih.gov/pubmed/10722515
https://ncbi.nlm.nih.gov/pmc/articles/PMC89817/
https://ncbi.nlm.nih.gov/pubmed/10722516
https://ncbi.nlm.nih.gov/pmc/articles/PMC89818/
https://ncbi.nlm.nih.gov/pubmed/10722517
https://ncbi.nlm.nih.gov/pmc/articles/PMC89819/
https://ncbi.nlm.nih.gov/pubmed/10722518
https://ncbi.nlm.nih.gov/pmc/articles/PMC89820/
https://ncbi.nlm.nih.gov/pubmed/10722519
https://ncbi.nlm.nih.gov/pmc/articles/PMC89821/
https://ncbi.nlm.nih.gov/pubmed/10722520
https://ncbi.nlm.nih.gov/pmc/articles/PMC89822/
https://ncbi.nlm.nih.gov/pubmed/10722521
https://ncbi.nlm.nih.gov/pmc/articles/PMC89823/
https://ncbi.nlm.nih.gov/pubmed/10722522
https://ncbi.nlm.nih.gov/pmc/articles/PMC89824/
https://ncbi.nlm.nih.gov/pubmed/10722523
https://ncbi.nlm.nih.gov/pmc/articles/PMC89825/
https://ncbi.nlm.nih.gov/pubmed/10722524
https://ncbi.nlm.nih.gov/pmc/articles/PMC89826/
https://ncbi.nlm.nih.gov/pubmed/10722525
https://ncbi.nlm.nih.gov/pmc/articles/PMC89827/
https://ncbi.nlm.nih.gov/pubmed/10722526
https://ncbi.nlm.nih.gov/pmc/articles/PMC89828/
https://ncbi.nlm.nih.gov/pubmed/10722527
https://ncbi.nlm.nih.gov/pmc/articles/PMC89829/
https://ncbi.nlm.nih.gov/pubmed/10799008
https://ncbi.nlm.nih.gov/pmc/articles/PMC89830/
https://ncbi.nlm.nih.gov/pubmed/10799009
https://ncbi.nlm.nih.gov/pmc/articles/PMC89831/
https://ncbi.nlm.nih.gov/pmc/articles/PMC89832/
https://ncbi.nlm.nih.gov/pubmed/10770739
https://ncbi.nlm.nih.gov/pmc/articles/PMC89833/
https://ncbi.nlm.nih.gov/pubmed/10770740
https://ncbi.nlm.nih.gov/pmc/articles/PMC89834/
https://ncbi.nlm.nih.gov/pubmed/10770741
https://ncbi.nlm.nih.gov/pmc/articles/PMC89835/
https://ncbi.nlm.nih.gov/pubmed/10770742
https://ncbi.nlm.nih.gov/pmc/articles/PMC89836/
https://ncbi.nlm.nih.gov/pubmed/10770743
https://ncbi.nlm.nih.gov/pmc/articles/PMC89837/
https://ncbi.nlm.nih.gov/pubmed/10770744
https://ncbi.nlm.nih.gov/pmc/articles/PMC89838/
https://ncbi.nlm.nih.gov/pubmed/10770745
https://ncbi.nlm.nih.gov/pmc/articles/PMC89839/
https://ncbi.nlm.nih.gov/pubmed/10770746
https://ncbi.nlm.nih.gov/pmc/articles/PMC89840/
https://ncbi.nlm.nih.gov/pubmed/10770747
https://ncbi.nlm.nih.gov/pmc/articles/PMC89841/
https://ncbi.nlm.nih.gov/pubmed/10770748
https://ncbi.nlm.nih.gov/pmc/articles/PMC89842/
https://ncbi.nlm.nih.gov/pubmed/10770749
https://ncbi.nlm.nih.gov/pmc/articles/PMC89843/
https://ncbi.nlm.nih.gov/pubmed/10770750
https://ncbi.nlm.nih.gov/pmc/articles/PMC89844/
https://ncbi.nlm.nih.gov/pubmed/10770751
https://ncbi.nlm.nih.gov/pmc/articles/PMC89845/
https://ncbi.nlm.nih.gov/pubmed/10770752
https://ncbi.nlm.nih.gov/pmc/articles/PMC89846/
https://ncbi.nlm.nih.gov/pubmed/10770753
https://ncbi.nlm.nih.gov/pmc/articles/PMC89847/
https://ncbi.nlm.nih.gov/pubmed/10770754

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