Salivary Histatin 5 and Human Neutrophil Defensin 1 Kill Candida albicans via Shared Pathways

Salivary histatins are a family of basic histidine-rich proteins in which therapeutic potential as drugs against oral candidiasis is apparent, considering their potent in vitro antifungal activity and lack of toxicity to humans. Histatin 5 (Hst 5) kills the fungal pathogen Candida albicans via a mec...

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Main Authors: Edgerton, Mira, Koshlukova, Svetlana E., Araujo, Marcelo W. B., Patel, Rashmi C., Dong, Jin, Bruenn, Jeremy A., Zhang, Lijuan, Dhillon, Pawandeep, Yan, Hong, Farmer, Susan, Hancock, Robert E. W., Masuda, Nobuhisa, Sakagawa, Eiko, Ohya, Satoshi, Gotoh, Naomasa, Tsujimoto, Hideto, Nishino, Takeshi, Deepe, George S., Gibbons, Reta, Sindelar, Georg, Zhao, Xilin, Liew, Anthony, Dong, Yuzhi, Lu, Tao, Zhou, Jianfeng, Domagala, John, Drlica, Karl, Ince, Dilek, Hooper, David C., Fung-Tomc, Joan C., Minassian, Beatrice, Kolek, Benjamin, Huczko, Elizabeth, Aleksunes, Lauren, Stickle, Terry, Washo, Thomas, Gradelski, Elizabeth, Valera, Lourdes, Bonner, Daniel P., Rachid, Shwan, Ohlsen, Knut, Witte, Wolfgang, Hacker, Jörg, Ziebuhr, Wilma, Rovaldi, C. R., Pievsky, A., Sole, N. A., Friden, P. M., Rothstein, D. M., Spacciapoli, P., DeLoney, Cindy R., Schiller, Neal L., Luh, Kwen-Tay, Hsueh, Po-Ren, Teng, Lee-Jene, Pan, Hui-Ju, Chen, Yu-Chi, Lu, Jang-Jih, Wu, Jiunn-Jong, Ho, Shen-Wu, Roberts, Jenna, Schock, Kathleen, Marino, Susan, Andriole, Vincent T., Martinez, Antonio, Aviles, Pablo, Jimenez, Elena, Caballero, Jesus, Gargallo-Viola, Domingo, Tait-Kamradt, A., Davies, T., Appelbaum, P. C., Depardieu, F., Courvalin, P., Petitpas, J., Wondrack, L., Walker, A., Jacobs, M. R., Sutcliffe, J., Fu, Lei, Cheng, Yung-Chi, Stevens, Dennis L., Smith, Leon G., Bruss, Jon B., McConnell-Martin, Maureen A., Duvall, Sue E., Todd, Wesley Mark, Hafkin, Barry, Simpson, Julie A., Watkins, Emmeline R., Price, Ric N., Aarons, Leon, Kyle, Dennis E., White, Nicholas J., Aarestrup, Frank Møller, Jensen, Lars Bogø, Maurin, M., Mersali, N. F., Raoult, D., Powell, S. K., Gates, M. E., Langford, G., Gu, M.-L., Lockey, C., Long, Z., Otto, E., Singh, Kavindra V., Zscheck, Karen K., Murray, Barbara E., Patel, Robin, Piper, Kerryl E., Rouse, Mark S., Steckelberg, James M., Mazzariol, Annarita, Tokue, Yutaka, Kanegawa, Tiffany M., Cornaglia, Giuseppe, Nikaido, Hiroshi, Dalla Costa, Libera M., Reynolds, Peter E., Souza, Helena A. P. H. M., Souza, Dilair C., Palepou, Marie-France I., Woodford, Neil, Snydman, D. R., Jacobus, N. V., McDermott, L. A., Lonks, J. R., Boyce, J. M., Savès, Marianne, Raffi, François, Clevenbergh, Philippe, Marchou, Bruno, Waldner-Combernoux, Anne, Morlat, Philippe, Le Moing, Vincent, Rivière, Catherine, Chêne, Geneviève, Leport, Catherine, Boyle-Vavra, Susan, Hahm, Jongin, Sibener, S. J., Daum, Robert S., Durand, Rémy, Eslahpazire, Jobin, Jafari, Sayeh, Delabre, Jean-François, Marmorat-Khuong, Anne, di Piazza, Jean-Philippe, Le Bras, Jacques, Meyer, Peter R., Matsuura, Suzanne E., Schinazi, Raymond F., So, Antero G., Scott, Walter A., Giacometti, Andrea, Cirioni, Oscar, Del Prete, Maria Simona, Barchiesi, Francesco, Scalise, Giorgio, Watts, Jeffrey L., Rossbach, Silvia, Geerdes-Fenge, Hilte F., Wiedersich, Axel, Wagner, S., Lehr, Karl-Heinz, Koeppe, Peter, Lode, Hartmut, García-Rey, C., Aguilar, L., Baquero, F., Teshager, Tirushet, Domínguez, Lucas, Moreno, Miguel A., Saénz, Yolanda, Torres, Carmen, Cardeñosa, Susana, Vester, Birte, Douthwaite, Stephen, Drusano, G. L., Preston, S. L., Hardalo, C., Hare, R., Banfield, C., Andes, D., Vesga, O., Craig, W. A., Odenholt, Inga, Löwdin, Elisabeth, Cars, Otto, Sadler, Brian M., Gillotin, Catherine, Lou, Yu, Stein, Daniel S., Koutsolioutsou, Anastasia, Martins, Elizabeth A., White, D. G., Levy, S. B., Demple, Bruce, Ichiyama, Takashi, Nishikawa, Miki, Yoshitomi, Tomomi, Hasegawa, Shunji, Matsubara, Tomoyo, Hayashi, Takashi, Furukawa, Susumu, Khan, Anis A., Slifer, Teri R., Araujo, Fausto G., Remington, Jack S., Marr, Kieren A., Lyons, Christopher N., Ha, Kien, Rustad, Tige R., White, Theodore C., Holz-Smith, Sonia L., Sun, I-Chen, Jin, Lei, Matthews, Thomas J., Lee, Kuo-Hsiung, Chen, Chin Ho, Credito, Kim L., Lin, Gengrong, Pankuch, Glenn A., Bajaksouzian, Saralee, Jacobs, Michael R., Appelbaum, Peter C., Leitch, Gordon J., Scanlon, Mary, Shaw, Andrew, Visvesvara, Govinda S., McNicholas, Paul M., Mann, Paul A., Najarian, David J., Miesel, Lynn, Hare, Roberta S., Black, Todd A., Neyts, Johan, De Clercq, Erik, Essack, Sabiha Y., Hall, Lucinda M. C., Pillay, Devadas G., McFadyen, Margaret Lynn, Livermore, David M., Baltch, A. L., Smith, R. P., Franke, M. A., Ritz, W. J., Michelsen, P. B., Bopp, L. H., Lomovskaya, Olga, Warren, Mark S., Lee, Angela, Galazzo, Jorge, Fronko, Richard, Lee, May, Blais, Johanne, Cho, Deidre, Chamberland, Suzanne, Renau, Tom, Leger, Roger, Hecker, Scott, Watkins, Will, Hoshino, Kazuki, Ishida, Hiroko, Lee, Ving J.
Formato: Artigo
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Publicado em: American Society for Microbiology 2000
Assuntos:
Mechanisms of Action: Physiological Effects
Mechanisms of Resistance
Biologic Response Modifiers
Susceptibility
Experimental Therapeutics
Antiviral Agents
Clinical Therapeutics
Pharmacology
Letters to the Editor
Minireviews
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