Divergence of Eukaryotic Secretory Components: the Candida albicans Homolog of the Saccharomyces cerevisiae Sec20 Protein Is N Terminally Truncated, and Its Levels Determine Antifungal Drug Resistance and Growth

Sec20p is a component of the yeast Saccharomyces cerevisiae secretory pathway that does not have a close homolog in higher eukaryotic cells. To verify the function of Sec20p in other fungal species, we characterized the gene encoding a Sec20p homolog in the human fungal pathogen Candida albicans. Th...

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Main Authors: Weber, Yvonne, Santore, Uwe J., Ernst, Joachim F., Swoboda, Rolf K., Villar, Maria T., Hirschberg, Rona L., Schaefer, Michael R., Fitzgerald, J. Ross, Monday, Steven R., Foster, Timothy J., Bohach, Gregory A., Hartigan, Patrick J., Meaney, William J., Smyth, Cyril J., Minakhin, Leonid, Nechaev, Sergei, Campbell, Elizabeth A., Severinov, Konstantin, Keenleyside, Wendy J., Clarke, Anthony J., Whitfield, Chris, Sardesai, Abhijit A., Gowrishankar, J., Saegusa, Haruhisa, Shiraki, Mari, Kanai, Chie, Saito, Terumi, Lumppio, Heather L., Shenvi, Neeta V., Summers, Anne O., Voordouw, Gerrit, Kurtz, Donald M., Eby, D. Matthew, Beharry, Zanna M., Coulter, Eric D., Neidle, Ellen L., Desvaux, Mickaël, Guedon, Emmanuel, Petitdemange, Henri, Spek, Erik J., Wright, Teresa L., Stitt, Molly S., Taghizadeh, Nazbeh R., Tannenbaum, Steven R., Marinus, Martin G., Engelward, Bevin P., Stanley, Nicola R., Findlay, Kim, Berks, Ben C., Palmer, Tracy, Ermakova-Gerdes, Svetlana, Yu, Zhenbao, Vermaas, Wim, Watanabe, Kunihiko, Yamamoto, Takeshi, Suzuki, Yuzuru, Stiefel, Alfred, Mahren, Susanne, Ochs, Martina, Schindler, Petra T., Enz, Sabine, Braun, Volkmar, Jiang, Ze-Yu, Bauer, Carl E., Behari, Jaideep, Stagon, Lisa, Calderwood, Stephen B., Butland, Gareth, Spiro, Stephen, Watmough, Nicholas J., Richardson, David J., Chalut, Christian, Charpentier, Xavier, Remy, Marie-Hélène, Masson, Jean-Michel, Tiennault-Desbordes, Emmanuelle, Cenatiempo, Yves, Laalami, Soumaya, Sy, Abdoulaye, Giraud, Eric, Jourand, Philippe, Garcia, Nelly, Willems, Anne, de Lajudie, Philippe, Prin, Yves, Neyra, Marc, Gillis, Monique, Boivin-Masson, Catherine, Dreyfus, Bernard, Cheng, Yulin, Dylla, Sara M., Turnbough, Charles L., Saviñón-Tejeda, Alma L., Ongay-Larios, Laura, Valdés-Rodríguez, Julián, Coria, Roberto, Naas, Thierry, Mikami, Yuzuru, Imai, Tamae, Poirel, Laurent, Nordmann, Patrice, Ma, Yan, Ludden, Paul W., Bardischewsky, Frank, Friedrich, Cornelius G., Kloser, Andrew W., Reading, Jared T., McDermott, Tom, Stidham, Rhesa, Misra, Rajeev, Jaspers, Marco C. M., Schmid, Andreas, Sturme, Mark H. J., Goslings, David A. M., Kohler, Hans-Peter E., Roelof van der Meer, Jan, Thiel, Teresa, Pratte, Brenda, Haseltine, Cynthia, Hill, Tiffany, Montalvo-Rodriguez, Rafael, Kemper, Samantha K., Shand, Richard F., Blum, Paul, Daugherty, Matthew, Vonstein, Veronika, Overbeek, Ross, Osterman, Andrei, Han, Mee-Jung, Yoon, Sang Sun, Lee, Sang Yup, Stabb, Eric V., Reich, Karl A., Ruby, Edward G., Delaney, Shannon M., Mavrodi, Dmitri V., Bonsall, Robert F., Thomashow, Linda S., Kolko, M. Miriam, Kapetanovich, Lori A., Lawrence, Jeffrey G., Seiflein, Thomas A., Sutton, Mark D., Kim, Melanie, Walker, Graham C., Tétart, Françoise, Desplats, Carine, Kutateladze, Mzia, Monod, Caroline, Ackermann, Hans-Wolfgang, Krisch, H. M., Wong, Kendy K. Y., Brinkman, Fiona S. L., Benz, Roland S., Hancock, Robert E. W., Steinke, Angelika, Grau, Sandra, Davidson, Amy, Hofmann, Eckhard, Ehrmann, Michael, Egland, Kristi A., Greenberg, E. P., Trott, Amy E., Stevens, Ann M., Xu, Xudong, Wolk, C. Peter, Arai, Kazuhito, Kamata, Takeo, Uchikoba, Hiroyuki, Fushinobu, Shinya, Matsuzawa, Hiroshi, Taguchi, Hayao, Hemmi, Hisashi, Yamashita, Satoshi, Shimoyama, Takefumi, Nakayama, Toru, Nishino, Tokuzo, Jones, Rheinallt M., Williams, Peter A., Herrero, Antonia, Muro-Pastor, Alicia M., Flores, Enrique, Jubier-Maurin, Véronique, Rodrigue, Agnès, Ouahrani-Bettache, Safia, Layssac, Marion, Mandrand-Berthelot, Marie-Andrée, Köhler, Stephan, Liautard, Jean-Pierre, Tinker, Juliette K., Hancox, Lisa S., Clegg, Steven
Formato: Artigo
Idioma:English
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Publicado em: American Society for Microbiology 2001
Assuntos:
Eukaryotic Cells
Genetics and Molecular Biology
Structure and Function
Enzymes and Proteins
Physiology and Metabolism
Cell Surfaces
Plant Microbiology
Plasmids and Transposons
General Microbiology
Bacteriophages
Errata
Minireviews
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