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Pure Botulinum Neurotoxin Is Absorbed from the Stomach and Small Intestine and Produces Peripheral Neuromuscular Blockade

Clostridium botulinum serotype A produces a neurotoxin composed of a 100-kDa heavy chain and a 50-kDa light chain linked by a disulfide bond. This neurotoxin is part of a ca. 900-kDa complex, formed by noncovalent association with a single nontoxin, nonhemagglutinin subunit and a family of hemagglut...

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Detalhes bibliográficos
Main Authors:	Maksymowych, Andrew B., Reinhard, Marco, Malizio, Carl J., Goodnough, Michael C., Johnson, Eric A., Simpson, Lance L., Hocking, D., Webb, E., Radcliff, F., Rothel, L., Taylor, S., Pinczower, G., Kapouleas, C., Braley, H., Lee, A., Doidge, C., Tu, Anh-Hue T., Fulgham, Robert L., McCrory, Mark A., Briles, David E., Szalai, Alexander J., Gase, Klaus, Ferretti, Joseph J., Primeaux, Charles, McShan, W. Michael, Rongrungruang, Yong, Levitz, Stuart M., Wann, Elisabeth R., Fehringer, Amy P., Ezepchuk, Yuri V., Schlievert, Patrick M., Bina, Paul, Reiser, Raoul F., Höök, Magnus M., Leung, Donald Y. M., Parad, Richard B., Gerard, Craig J., Zurakowski, David, Nichols, David P., Pier, Gerald B., Wang, Ying, Huang, Sheng-He, Wass, Carol A., Stins, Monique F., Kim, Kwang Sik, Arroll, Thomas W., Centurion-Lara, Arturo, Lukehart, Sheila A., Van Voorhis, Wesley C., Manoutcharian, Karen, Terrazas, Luis Ignacio, Gevorkian, Goar, Acero, Gonzalo, Petrossian, Pavel, Rodriguez, Miriam, Govezensky, Tzipe, Tetteh, Kevin K. A., Loukas, Alex, Tripp, Cindy, Maizels, Rick M., Li, Zhongming, Howard, Angela, Kelley, Cynthia, Delogu, Giovanni, Collins, Frank, Morris, Sheldon, Condon, Michael R., Viera, Alejandro, D’Alessio, Michael, Diamond, Gill, Buommino, Elisabetta, Morelli, Francesco, Metafora, Salvatore, Rossano, Fabio, Perfetto, Brunella, Baroni, Adone, Tufano, Maria Antonietta, Fields, Kenneth A., Straley, Susan C., Schenkein, Harvey A., Gunsolley, John C., Best, Al M., Harrison, M. Travis, Hahn, Chin-Lo, Wu, Jiuhua, Tew, John G., Aliberti, Júlio C. S., Machado, Fabiana S., Souto, Janeusa T., Campanelli, Ana P., Teixeira, Mauro M., Gazzinelli, Ricardo T., Silva, João S., Jia, Hong Peng, Mills, Jesse N., Barahmand-Pour, Fariba, Nishimura, Darryl, Mallampali, Rama K., Wang, Guoshun, Wiles, Kerry, Tack, Brian F., Bevins, Charles L., McCray, Paul B., Kresse, Andreas U., Rohde, Manfred, Guzmán, Carlos A., Bøe, Roald, Silvola, Juha, Yang, Jinghui, Moens, Ugo, Stenfors, Lars-Eric, Seljfelid, Rolf, Mesnage, Stéphane, Weber-Levy, Martine, Haustant, Michel, Mock, Michèle, Fouet, Agnès, Buchrieser, Carmen, Rusniok, Christophe, Frangeul, Lionel, Couve, Elisabeth, Billault, Alain, Kunst, Frank, Carniel, Elisabeth, Glaser, Philippe, McCool, Tera L., Harding, Clifford V., Greenspan, Neil S., Schreiber, John R., Herrero, Ana B., López, M. Carmen, García, Susana, Schmidt, Axel, Spaltmann, Frank, Ruiz-Herrera, José, Dominguez, Angel, Tsolis, Renée M., Adams, L. Garry, Ficht, Thomas A., Bäumler, Andreas J., Gao, Lian-Yong, Abu Kwaik, Yousef, Birkness, Kristin A., Swords, W. Edward, Huang, Pei-Hsiu, White, Elizabeth H., Dezzutti, Charlene S., Lal, Renu B., Quinn, Frederick D., Ellemor, Darren M., Baird, Rebecca N., Awad, Milena M., Boyd, Richard L., Rood, Julian I., Emmins, John J., Pereira, Cátia M., Favoreto, Sílvio, Franco da Silveira, José, Yoshida, Nobuko, Castilho, Beatriz A., Bermudez, Luiz E., Goodman, Joseph, Petrofsky, Mary, Kontani, Masanori, Amano, Atsuo, Nakamura, Takayuki, Nakagawa, Ichiro, Kawabata, Shigetada, Hamada, Shigeyuki, Ahlstedt, Ingela, Lindholm, Catharina, Lönroth, Hans, Hamlet, Annika, Svennerholm, Ann-Mari, Quiding-Järbrink, Marianne, Chen, Wen, Kuramitsu, Howard K., Bishai, William R., Dannenberg, Arthur M., Parrish, Nikki, Ruiz, Rafael, Chen, Ping, Zook, Bernard C., Johnson, Walter, Boles, James W., Pitt, M. Louise M., Lottenbach, Kathleen R., Mink, ChrisAnna M., Barenkamp, Stephen J., Anderson, Edwin L., Homan, Sharon M., Powers, Douglas C., Santiago, H. C., Oliveira, M. A. P., Bambirra, E. A., Faria, A. M. C., Afonso, L. C. C., Vieira, L. Q., Gazzinelli, R. T., Chung, Gyung-Tae, Franco, Augusto A., Wu, Shaoguang, Rhie, Gi-Eun, Cheng, Rodney, Oh, Hee-Bok, Sears, Cynthia L., Watson, Patricia R., Paulin, Sue M., Bland, A. Patricia, Libby, Stephen J., Jones, Philip W., Wallis, Tim S., Cadieux, Nathalie, Plante, Martin, Rioux, Clément R., Hamel, Josée, Brodeur, Bernard R., Martin, Denis, Tibor, Anne, Decelle, Béatrice, Letesson, Jean-Jacques, San Mateo, Lani R., Toffer, Kristen L., Orndorff, Paul E., Kawula, Thomas H., Zeng, Hui, Pandher, Karamjeet, Murphy, George L., Nowicki, Stella, Selvarangan, Rangaraj, Anderson, Garland, Perkins, Douglas J., Kremsner, Peter G., Schmid, Daniela, Misukonis, Mary A., Kelly, Meghan A., Weinberg, J. Brice, Abul-Milh, Maan, Paradis, Sonia-Élaine, Dubreuil, J. Daniel, Jacques, Mario, Steeghs, Liana, Kuipers, Betsy, Hamstra, Hendrik Jan, Kersten, Gideon, van Alphen, Loek, van der Ley, Peter, Merkel, Glenn J., Scofield, Barbara A., Kiser, Kevin B., Cantey-Kiser, Jean M., Lee, Jean C., Fromen-Romano, Cécile, Drevet, Pascal, Robert, Alain, Ménez, André, Léonetti, Michel, Simpson, Waltena, Wang, Chin-Yen, Mikolajczyk-Pawlinska, Jowita, Potempa, Jan, Travis, James, Bond, Vincent C., Genco, Caroline Attardo
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	American Society for Microbiology 1999
Assuntos:	Molecular and Cellular Pathogenesis Microbial Immunity and Vaccines Bacterial Infections Fungal and Parasitic Infections Host Response and Inflammation Molecular Genomics
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC96798/ https://ncbi.nlm.nih.gov/pubmed/10456920 https://ncbi.nlm.nih.gov/pmc/articles/PMC96799/ https://ncbi.nlm.nih.gov/pubmed/10456921 https://ncbi.nlm.nih.gov/pmc/articles/PMC96800/ https://ncbi.nlm.nih.gov/pubmed/10456922 https://ncbi.nlm.nih.gov/pmc/articles/PMC96801/ https://ncbi.nlm.nih.gov/pubmed/10456923 https://ncbi.nlm.nih.gov/pmc/articles/PMC96802/ https://ncbi.nlm.nih.gov/pubmed/10456924 https://ncbi.nlm.nih.gov/pmc/articles/PMC96803/ https://ncbi.nlm.nih.gov/pubmed/10456925 https://ncbi.nlm.nih.gov/pmc/articles/PMC96804/ https://ncbi.nlm.nih.gov/pubmed/10456926 https://ncbi.nlm.nih.gov/pmc/articles/PMC96805/ https://ncbi.nlm.nih.gov/pubmed/10456927 https://ncbi.nlm.nih.gov/pmc/articles/PMC96806/ https://ncbi.nlm.nih.gov/pubmed/10456928 https://ncbi.nlm.nih.gov/pmc/articles/PMC96807/ https://ncbi.nlm.nih.gov/pubmed/10456929 https://ncbi.nlm.nih.gov/pmc/articles/PMC96808/ https://ncbi.nlm.nih.gov/pubmed/10456930 https://ncbi.nlm.nih.gov/pmc/articles/PMC96809/ https://ncbi.nlm.nih.gov/pubmed/10456931 https://ncbi.nlm.nih.gov/pmc/articles/PMC96810/ https://ncbi.nlm.nih.gov/pubmed/10456932 https://ncbi.nlm.nih.gov/pmc/articles/PMC96811/ https://ncbi.nlm.nih.gov/pubmed/10456933 https://ncbi.nlm.nih.gov/pmc/articles/PMC96812/ https://ncbi.nlm.nih.gov/pubmed/10456934 https://ncbi.nlm.nih.gov/pmc/articles/PMC96813/ https://ncbi.nlm.nih.gov/pubmed/10456935 https://ncbi.nlm.nih.gov/pmc/articles/PMC96814/ https://ncbi.nlm.nih.gov/pubmed/10456936 https://ncbi.nlm.nih.gov/pmc/articles/PMC96815/ https://ncbi.nlm.nih.gov/pubmed/10456937 https://ncbi.nlm.nih.gov/pmc/articles/PMC96816/ https://ncbi.nlm.nih.gov/pubmed/10456938 https://ncbi.nlm.nih.gov/pmc/articles/PMC96817/ https://ncbi.nlm.nih.gov/pubmed/10456939 https://ncbi.nlm.nih.gov/pmc/articles/PMC96818/ https://ncbi.nlm.nih.gov/pubmed/10456940 https://ncbi.nlm.nih.gov/pmc/articles/PMC96819/ https://ncbi.nlm.nih.gov/pubmed/10456941 https://ncbi.nlm.nih.gov/pmc/articles/PMC96820/ https://ncbi.nlm.nih.gov/pubmed/10456942 https://ncbi.nlm.nih.gov/pmc/articles/PMC96821/ https://ncbi.nlm.nih.gov/pubmed/10456943 https://ncbi.nlm.nih.gov/pmc/articles/PMC96822/ https://ncbi.nlm.nih.gov/pubmed/10456944 https://ncbi.nlm.nih.gov/pmc/articles/PMC96823/ https://ncbi.nlm.nih.gov/pubmed/10456945 https://ncbi.nlm.nih.gov/pmc/articles/PMC96824/ https://ncbi.nlm.nih.gov/pubmed/10456946 https://ncbi.nlm.nih.gov/pmc/articles/PMC96825/ https://ncbi.nlm.nih.gov/pubmed/10456947 https://ncbi.nlm.nih.gov/pmc/articles/PMC96826/ https://ncbi.nlm.nih.gov/pubmed/10456948 https://ncbi.nlm.nih.gov/pmc/articles/PMC96827/ https://ncbi.nlm.nih.gov/pubmed/10456949 https://ncbi.nlm.nih.gov/pmc/articles/PMC96828/ https://ncbi.nlm.nih.gov/pubmed/10456950 https://ncbi.nlm.nih.gov/pmc/articles/PMC96829/ https://ncbi.nlm.nih.gov/pubmed/10456951 https://ncbi.nlm.nih.gov/pmc/articles/PMC96830/ https://ncbi.nlm.nih.gov/pubmed/10456952 https://ncbi.nlm.nih.gov/pmc/articles/PMC96831/ https://ncbi.nlm.nih.gov/pubmed/10456953 https://ncbi.nlm.nih.gov/pmc/articles/PMC96832/ https://ncbi.nlm.nih.gov/pubmed/10456954 https://ncbi.nlm.nih.gov/pmc/articles/PMC96833/ https://ncbi.nlm.nih.gov/pubmed/10456955 https://ncbi.nlm.nih.gov/pmc/articles/PMC96834/ https://ncbi.nlm.nih.gov/pubmed/10456956 https://ncbi.nlm.nih.gov/pmc/articles/PMC96835/ https://ncbi.nlm.nih.gov/pubmed/10456957 https://ncbi.nlm.nih.gov/pmc/articles/PMC96836/ https://ncbi.nlm.nih.gov/pubmed/10456958 https://ncbi.nlm.nih.gov/pmc/articles/PMC96837/ https://ncbi.nlm.nih.gov/pubmed/10456959 https://ncbi.nlm.nih.gov/pmc/articles/PMC96838/ https://ncbi.nlm.nih.gov/pubmed/10456960 https://ncbi.nlm.nih.gov/pmc/articles/PMC96839/ https://ncbi.nlm.nih.gov/pubmed/10456961 https://ncbi.nlm.nih.gov/pmc/articles/PMC96840/ https://ncbi.nlm.nih.gov/pubmed/10456962 https://ncbi.nlm.nih.gov/pmc/articles/PMC96841/ https://ncbi.nlm.nih.gov/pubmed/10456963 https://ncbi.nlm.nih.gov/pmc/articles/PMC96842/ https://ncbi.nlm.nih.gov/pubmed/10496867 https://ncbi.nlm.nih.gov/pmc/articles/PMC96843/ https://ncbi.nlm.nih.gov/pubmed/10496868 https://ncbi.nlm.nih.gov/pmc/articles/PMC96844/ https://ncbi.nlm.nih.gov/pubmed/10496869 https://ncbi.nlm.nih.gov/pmc/articles/PMC96845/ https://ncbi.nlm.nih.gov/pubmed/10496870 https://ncbi.nlm.nih.gov/pmc/articles/PMC96846/ https://ncbi.nlm.nih.gov/pubmed/10496871 https://ncbi.nlm.nih.gov/pmc/articles/PMC96847/ https://ncbi.nlm.nih.gov/pubmed/10496872
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Pure Botulinum Neurotoxin Is Absorbed from the Stomach and Small Intestine and Produces Peripheral Neuromuscular Blockade

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