In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot

Abstract Chemical probes are an indispensable tool for translating biological discoveries into new therapies, though are increasingly difficult to identify since novel therapeutic targets are often hard-to-drug proteins. We introduce FRASE-based hit-finding robot (FRASE-bot), to expedite drug discov...

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Udgivet i:Nature Communications
Main Authors: Yi An, Jiwoong Lim, Marta Glavatskikh, Xiaowen Wang, Jacqueline Norris-Drouin, P. Brian Hardy, Tina M. Leisner, Kenneth H. Pearce, Dmitri Kireev
Format: Artigo
Udgivet: Nature Portfolio 2024-07-01
Online adgang:https://doi.org/10.1038/s41467-024-49892-9
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https://doi.org/10.1038/s41467-024-49892-9

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