Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding.

1. 2-(N'-Acetyl-L-phenylalanylamino)ethyl 2'-pyridyl disulphide [compound (III)] and 2-(acetamido)ethyl 2'-pyridyl disulphide [compound (IV)] were synthesized by acylation of the common intermediate, 2-aminoethyl 2'-pyridyl disulphide, to provide examples of chromogenic thiol-spe...

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Detalhes bibliográficos
Main Authors: Brocklehurst, K, Kowlessur, D, O'Driscoll, M, Patel, G, Quenby, S, Salih, E, Templeton, W, Thomas, E W, Willenbrock, F
Formato: Artigo
Idioma:English
Publicado em: 1987
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1147969/
https://ncbi.nlm.nih.gov/pubmed/3663111
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1147969/
https://ncbi.nlm.nih.gov/pubmed/3663111

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