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Characterization of the wild-type form of 4a-carbinolamine dehydratase and two naturally occurring mutants associated with hyperphenylalaninemia.

The characterization of 4a-carbinolamine dehydratase with the enzymatically synthesized natural substrate revealed non-Michaelis-Menten kinetics. A Hill coefficient of 1.8 indicates that the dehydratase exists as a multisubunit enzyme that shows cooperativity. A mild form of hyperphenylalaninemia wi...

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Detalhes bibliográficos
Main Authors: Johnen, G, Kowlessur, D, Citron, B A, Kaufman, S
Formato: Artigo
Idioma:en
Publicado em: 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC40362/
https://ncbi.nlm.nih.gov/pubmed/8618906
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