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mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling
High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR inhibi...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
2015
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593396/ https://ncbi.nlm.nih.gov/pubmed/25425103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-014-1066-0 |
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