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mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling
High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR inhibi...
Uloženo v:
| Médium: | Článek |
|---|---|
| Jazyk: | en |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593396/ https://ncbi.nlm.nih.gov/pubmed/25425103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-014-1066-0 |
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